Publications by authors named "Katrin Goetz"
Article Synopsis
- The study reveals that environmental interactions significantly influence the development of precursor cells in the nervous system, affecting their cellular diversity.
- Different growth substrates, like laminin and fibronectin, play a crucial role in guiding neural fate and neuron functionality as development progresses.
- These findings suggest that the changes observed in neural cells mimic early embryonic brain interactions and may clarify why certain brain structures are defined by specific extracellular matrix components during development.
Slice culture model systems provide a unique opportunity to monitor and lesion brain circuits in a dish. Using a novel approach, we have generated parasagittal slices from mouse brains that preserve, throughout the culture process, the nigrostriatal circuit. These slices can be cultured for approximately 4 weeks with maintenance of normal neuronal cytoarchitecture.
View Article and Find Full Text PDFPhenotypic and functional characterization of adult brain neuropoiesis.
Proc Natl Acad Sci U S A
June 2005
The modern concept of neurogenesis in the adult brain is predicated on the premise that multipotent glial cells give rise to new neurons throughout life. Although extensive evidence exists indicating that this is the case, the transition from glial to neuronal phenotype remains poorly understood. A unique monolayer cell-culture system was developed to induce, expose, and recapitulate the entire developmental series of events of subventricular zone (SVZ) neurogenesis.
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