Publications by authors named "Katri Saukkonen"
Heme oxygenase 1 (HO-1) is a cytoprotective enzyme upregulated by various critical illness-related stress stimuli. We investigated the association of HO-1 gene polymorphisms and plasma concentrations with the outcome of critically ill patients in a prospective cohort study of 231 critically ill patients admitted to tertiary care medical and medical-surgical intensive care units. Blood samples were collected on days 1, 2, and 3 to 4 in the intensive care unit.
View Article and Find Full Text PDFBackground: Increased concentrations of cell-free DNA have been found in plasma of septic and critically ill patients. We investigated the value of plasma DNA for the prediction of intensive care unit (ICU) and hospital mortality and its association with the degree of organ dysfunction and disease severity in patients with severe sepsis.
Methods: We studied 255 patients with severe sepsis or septic shock.
Objective: To investigate the concentration of cell-free plasma DNA and its association with organ dysfunction and hospital mortality in intensive care unit patients.
Design And Setting: Prospective cohort study in a medical and two medical-surgical intensive care units in a university hospital.
Patients: 228 critically ill patients admitted to the ICUs between January 2004 and July 2005.
Objective: To assess the impact of hemodynamic variables on the outcome of critically ill patients in septic shock and to identify the optimal threshold values related to outcome with special reference to continuously monitored mean arterial pressure (MAP) and mixed venous oxygen saturation (SvO2).
Design And Setting: Retrospective cohort study in a university hospital intensive care unit (ICU).
Patients: All consecutive 111 patients with septic shock treated in our ICU between 1 Jan.