Effects of Δ-Tetrahydrocannabinol and the Aminoalkylindole K2/Spice Constituent JWH-073 on Cardiac Tissue and Mesenteric Vascular Reactivity.

Although use of is not associated with serious adverse effects, recreational use of aminoalkylindole (AAI) cannabinoid receptor agonists found in K2/Spice herbal blends has been reported to cause adverse cardiovascular events, including angina, arrhythmia, changes in blood pressure, ischemic stroke, and myocardial infarction. Δ-Tetrahydrocannabinol (Δ-THC) is the primary CB agonist found in cannabis and JWH-073 is one of the AAI CB agonists found in K2/Spice brands sold to the public. This study used , , and approaches to investigate potential differences on cardiac tissue and vascular effects betweenJWH-073 and Δ-THC.