Blood stream Infections in chronic hemodialysis patients - characteristics and outcomes.

Introduction: Bloodstream Infections (BSI) are a major cause of death and hospitalization among hemodialysis (HD) patients. The rates of BSI among HD patients vary and are influenced by local patient and pathogen characteristics. Modifications in local infection prevention protocols in light of active surveillance of BSI has been shown to improve clinical outcomes.

Targeted therapy with nanatinostat and valganciclovir in recurrent EBV-positive lymphoid malignancies: a phase 1b/2 study.

Lymphomas are not infrequently associated with the Epstein-Barr virus (EBV), and EBV positivity is linked to worse outcomes in several subtypes. Nanatinostat is a class-I selective oral histone deacetylase inhibitor that induces the expression of lytic EBV BGLF4 protein kinase in EBV+ tumor cells, activating ganciclovir via phosphorylation, resulting in tumor cell apoptosis. This phase 1b/2 study investigated the combination of nanatinostat with valganciclovir in patients aged ≥18 years with EBV+ lymphomas relapsed/refractory to ≥1 prior systemic therapy with no viable curative treatment options.

Association of Nutrition Status at Dialysis Start With Long-Term Survival: A 10-Year Retrospective Study.

Objective: The objectives of the study are to explore the association between nutritional status at the initiation of dialysis and the improvement or worsening of nutrition status during first 3 months of dialysis and first 5 years of survival on dialysis.

Methods: Two hundred ninety-seven patients who started dialysis between March 2009 and March 2019 were enrolled in the study. The nutritional status of the patients at dialysis commencement was evaluated by the method of The Integrative Clinical Nutrition Dialysis Score (ICNDS).

The effect of hemodialysis on individual retinal layer thickness.

Purpose: The aim of this study was to employ newly developed advanced image analysis software to evaluate changes in retinal layer thickness following hemodialysis.

Methods: A non-randomized prospective study of patients with end-stage renal disease assessed on the same day before and after hemodialysis. Intraocular pressure and central corneal thickness were analyzed, and spectral domain optical coherence tomography results were automatically segmented using the Orion software and then compared.

Intermittent systemic hypoxic-hyperoxic training for myocardial protection in patients undergoing coronary artery bypass surgery: first results from a single-centre, randomised controlled trial.

Background: Although remote ischaemic preconditioning (RIP) provides protection against myocardial ischaemia and reperfusion injury during cardiac surgery, it is not widely used. Systemic intermittent hypoxic-hyperoxic training (IHHT) may be a suitable alternative.

Methods: This is a prospective, single-centre, randomised controlled trial.

Phosphate binders, appetite and nutritional status in maintenance hemodialysis patients.

Background And Objectives: The potential side effects of common phosphate binders are gastrointestinal in practice. We hypothesized that regular use of phosphate binders may be associated with decreased appetite, dietary intake and consequently, poor nutritional status.

Methods And Study Design: This was cross-sectional study of 78 patients (mean age 67.

Estimating of Residual Kidney Function by Multi-Frequency Bioelectrical Impedance Analysis in Hemodialysis Patients Without Urine Collection.

Background/aims: Residual kidney function (RKF) is a pivotal predictor of better clinical outcomes in maintenance hemodialysis (MHD) patients. So far there has been no attempt to use bioimpedance analysis (BIA) measurements to calculate residual glomerular filtration rate (GFR) in dialysis population. We hypothesized that performing of multi-frequency BIA at the beginning and end of hemodialysis session can enable us to predict the measured residual GFR in MHD patients.

Age modifies the association between serum obestatin, appetite and nutritional status in maintenance hemodialysis patients.

Background/objectives: Increased age is strongly associated with anorexia and protein-energy wasting (PEW) in maintenance hemodialysis (MHD) population. We hypothesized that the association of obestatin, a recently discovered anorexigenic gut hormone, with appetite and nutritional status differs by age groups.

Subjects/methods: We performed a cross-sectional study on 261MHD patients.

[The results of pulmonary veins isolation to prevent postoperative atrial fibrillation].

Aim: To compare an efficacy of primary surgical (epicardial bipolar pulmonary veins isolation) and pharmacological (amiodarone) prevention of postoperative atrial fibrillation.

Material And Methods: The study included 117 patients with coronary artery disease without previous paroxysms of atrial fibrillation who were randomized into 3 groups. The first (I) group (n=39) included patients who underwent coronary artery bypass grafting without radiofrequency ablation of pulmonary veins and prophylactic amiodarone administration.

[Long-term results of surgical treatment of patients with aortic valve disease and functional mitral insufficiency].

Aim: To analyze long-term surgical results in patients with aortic valve disease and concomitant mitral regurgitation (MR) depending on volume of valve surgery.

Material And Methods: It was studied 5-year results in 71 patients with aortic valve disease and different degree of mitral regurgitation. Patients were divided into 3 groups.

[Reverse myocardial remodeling in patients with aortic valve disease and mitral insufficiency in early postoperative period].

Surgical treatment of patients with aortic valve disease and concomitant mitral insufficiency remains debatable. We analyzed early postoperative results of surgical treatment of 80 patients depending on type of surgery. All patients were divided into three groups: the 1st - aortic valve replacement in patients without mitral valve dysfunction (control group) (n=44); the 2nd - isolated aortic valve replacement in patients with concomitant mitral regurgitation degree 2-3 (n=18), the 3rd - simultaneous aortic and mitral valve replacement (n=18).

[Aortic-bicarotid-subclavian trifurcation bypass grafting with a synthetic prosthesis].

The authors describe herein a case of successful surgical management of a 55-year-old male patient presenting with a multifocal atherosclerotic lesion of brachiocephalic arteries. The diagnosis was confirmed by DS with CDM, MSCT angiography. Intraoperatively revealed were up to 80% stenosis of the ostium of the left common carotid artery and up to 80% stenosis of the brachiocephalic trunk.

[Subacute infectious endocarditis of unusual etiology: peculiarities of diagnostics and treatment].

Infectious endocarditis (IE) is an inflammatory disease of cardiac valves and endocardium of different origin. Subacute IE is a specific form of sepsis associated with the presence of the site of infection in the heart responsible for recurrent septicemia, embolism, and progressive changes in the immune system leading to nephritis, vasculitis, synovitis, and polyserositis. This form develops in response to a low-virulent pathogen (e.

[Clinico-diagnostic significance of high-molecular mucin CA19-9 blood level in patients with breast diseases].

Blood samples of 212 patients with breast lesions (32 patients had benign lesions and 180 - malignant breast tumors) were analyzed. Benign breast diseases corresponded to fabroadenoma, cyst and diffuse mastopathy. Among those with breast cancer I-IIa stages of the disease was diagnosed in 80 patients, IIb - in 34, IIIa and IIIb stages - in 9 and 38 cases, correspondingly, stage IV was diagnosed in 19 patients.

[Transection of secondary chordae of anterior mitral valve leaflet as a method of correction of functional mitral insufficiency during resection of left ventricular aneurism].

Dominating factor of development of functional mitral insufficiency in patients with ischemic heart disease and dilated cardiomyopathy is deformation of atrioventricular valve leaflets due to traction by chordae apparatus. In patients candidates for left ventricular reconstruction because of its postinfarction aneurism the problem of preexisting or recurrent dysfunction of mitral valve acquires special value as operation itself implies surgical ventricular remodeling and therefore change of mitral valve geometry. Supplementation of the volume of surgical intervention with resection of chordae responsible for impaired coaptation of mitral valve leaflets in some cases appears to be effective and simple method of correction of mitral insufficiency.

[The evaluation of the late effect of the multiple administration of immunoglobulin on hepatitis A morbidity in organized collectives].

The analysis of influence in multiple injections of immunoglobulin (IG) on a level of morbidity and the efficiency of IG prophylaxis against hepatitis A in organized collectives made it possible to reveal the following common features: there is a direct dependency between morbidity level and average geometrical anti-IG titers, as well as the number of injections; there is inverse dependency between IG protection activity and the same factors; there is a lack of prophylaxis effect in anti-IG titers 1:32 or more. The authors frame a hypothesis that the reason of epidemic upgrowth of long standing hepatitis A morbidity dynamics in military collectives was conditioned by the wide application of IG in the 70s for children and teenagers.

[The modulation of the interferon system by gamma-globulin preparations].

Preparations of specific and commercial gamma-globulin against hepatitis A virus caused a marked inhibition of alpha- and gamma-links of the IF system 7 days after administration. In 80% of the subjects given commercial gamma-globulin 14 days after administration the above values returned to those observed before administration of the preparations. The recovery of the leukocyte capacity for alpha-IF production after administration of specific gamma-globulin was observed only in 50% of the subjects examined, while inhibition of the gamma-link of IF system persisted for 14 days (50%) or showed a poor trend to restoration not reaching the initial levels.