Phenol (bio)isosteres in drug design and development.

Due to their versatile properties, phenolic compounds are integral to various biologically active molecules, including many pharmaceuticals. However, their application in drug design is often hindered by issues such as poor oral bioavailability, rapid metabolism, and potential toxicity. This review explores the use of phenol bioisosteres-structurally similar compounds that can mimic the biological activity of phenols while potentially offering improved drug-like properties.

The DOES Scale: Measuring Sensory Processing Sensitivity as a Trait Constellation.

Based on Aron's (2020) DOES model, we developed the DOES Scale to measure Sensory Processing Sensitivity (SPS) with four dimensions: Depth of Processing, Overstimulation, Emotional Reactivity, and Sensing the Subtle. Using interview data from the study by Roth et al. (2023), we created a 20-item questionnaire (5 items per dimension) in German and English.

Embracing the Emotion in Emotional Intelligence Measurement: Insights from Emotion Theory and Research.

Emotional intelligence (EI) has gained significant popularity as a scientific construct over the past three decades, yet its conceptualization and measurement still face limitations. Applied EI research often overlooks its components, treating it as a global characteristic, and there are few widely used performance-based tests for assessing ability EI. The present paper proposes avenues for advancing ability EI measurement by connecting the main EI components to models and theories from the emotion science literature and related fields.

How Speededness of a Reasoning Test and the Complexity of Mental Speed Tasks Influence the Relation between Mental Speed and Reasoning Ability.

Although previous research has consistently reported a positive association between mental speed and reasoning ability, it remains unclear whether the magnitude of this association depends on whether the reasoning test is administered with or without a time limit. In addition, it is unknown how mental speed task complexity affects the mental speed-reasoning association when the effects of time limitations in the reasoning test (labeled "speededness") are controlled for. The present study examined these questions in a sample of 200 participants who completed the time-limited Culture Fair Test (CFT) and a Hick task with three levels of complexity to measure mental speed.

Parallel Evolution of Pseudomonas aeruginosa during a Prolonged ICU-Infection Outbreak.

Most knowledge about Pseudomonas aeruginosa pathoadaptation is derived from studies on airway colonization in cystic fibrosis; little is known about adaptation in acute settings. P. aeruginosa frequently affects burned patients and the burn wound niche has distinct properties that likely influence pathoadaptation.

The relationship between medical students' empathy, mental health, and burnout: A cross-sectional study.

Objective: To investigate how medical students' empathy is related to their mental health and burnout.

Methods: This cross-sectional study included 886 medical students from curriculum years 1-6. The cognitive, affective, and behavioural dimensions of empathy were measured with self-report questionnaires and an emotion recognition test.

Assessing Emotional Intelligence Abilities, Acquiescent and Extreme Responding in Situational Judgment Tests Using Principal Component Metrics.

Principal Component Metrics is a novel theoretically-based and data-driven methodology that enables the evaluation of the internal structure at item level of maximum emotional intelligence tests. This method disentangles interindividual differences in emotional ability from acquiescent and extreme responding. Principal Component Metrics are applied to existing (Mayer-Salovey-Caruso Emotional Intelligence Test) and assembled (specifically, the Situational Test of Emotion Understanding, the Situational Test of Emotion Management, and the Geneva Emotion Recognition Test) emotional intelligence test batteries in an analysis of three samples (total = 2,303 participants).

Adult Attachment and Personality as Predictors of Jealousy in Romantic Relationships.

Functional relationships between romantic jealousy and traits, such as neuroticism or adult attachment styles, are well-known. For the first time, we conducted a joint analysis of the Big Five traits and attachment dimensions as predictors of jealousy, which considered gender differences as well as differences in infidelity experiences and relationship status. In 847 participants, path modeling showed that higher neuroticism, lower agreeableness, and lower openness predicted higher romantic jealousy.

Reduced emotion recognition from nonverbal cues in anorexia nervosa.

Objective: Recent models of anorexia nervosa (AN) emphasise the role of reduced emotion recognition ability (ERA) in the development and maintenance of the disorder. However, methodological limitations impede conclusions from prior research. The current study tries to overcome these limitations by examining ERA with an audio-visual measure that focuses strictly on multimodal nonverbal cues and allows to differentiate between ERA for different emotion categories.

How Multidimensional Is Emotional Intelligence? Bifactor Modeling of Global and Broad Emotional Abilities of the Geneva Emotional Competence Test.

Drawing upon multidimensional theories of intelligence, the current paper evaluates if the Geneva Emotional Competence Test (GECo) fits within a higher-order intelligence space and if emotional intelligence (EI) branches predict distinct criteria related to adjustment and motivation. Using a combination of classical and S-1 bifactor models, we find that (a) a first-order oblique and bifactor model provide excellent and comparably fitting representation of an EI structure with self-regulatory skills operating independent of general ability, (b) residualized EI abilities uniquely predict criteria over general cognitive ability as referenced by fluid intelligence, and (c) emotion recognition and regulation incrementally predict grade point average (GPA) and affective engagement in opposing directions, after controlling for fluid general ability and the Big Five personality traits. Results are qualified by psychometric analyses suggesting only emotion regulation has enough determinacy and reliable variance beyond a general ability factor to be treated as a manifest score in analyses and interpretation.

Experimental phasing with vanadium and application to nucleotide-binding membrane proteins.

The structure determination of soluble and membrane proteins can be hindered by the crystallographic phase problem, especially in the absence of a suitable homologous structure. Experimental phasing is the method of choice for novel structures; however, it often requires heavy-atom derivatization, which can be difficult and time-consuming. Here, a novel and rapid method to obtain experimental phases for protein structure determination by vanadium phasing is reported.

Loneliness and Well-Being During the Covid-19 Pandemic: Associations with Personality and Emotion Regulation.

The present study examined how neuroticism, extraversion, and emotion regulation were related to loneliness and well-being during 6 weeks of major public life restrictions in the Covid-19 pandemic in Switzerland. Cross-sectional results from 466 participants showed that neuroticism and emotion regulation strategies were associated with higher loneliness and lower well-being. However, in contrast to prior research, associations of extraversion with loneliness and well-being were weak and were qualified by interactions with emotion regulation.

Accuracy in Judging Others' Personalities: The Role of Emotion Recognition, Emotion Understanding, and Trait Emotional Intelligence.

The ability to accurately judge others' personality and the ability to accurately recognize others' emotions are both part of the broader construct of interpersonal accuracy (IPA). However, little research has examined the association between these two IPA domains. Little is also known about the relationship between personality judgment accuracy and other socio-emotional skills and traits.

Speeded reasoning moderates the inverse relationship between autistic traits and emotion recognition.

Autistic people typically have difficulty recognizing other people's emotions and to process nonverbal cues in an automatic, intuitive fashion. This usually also applies to people who-regardless of an official diagnosis of autism-achieve high values in autism questionnaires. However, some autistic people do not seem to have any problems with emotion recognition.

Improving emotion recognition in anorexia nervosa: An experimental proof-of-concept study.

Objective: Previous research has found increasing evidence for difficulties in emotion recognition ability (ERA) and social cognition in anorexia nervosa (AN), and recent models consider these factors to contribute to the development and maintenance of the disorder. However, there is a lack of experimental studies testing this hypothesis. Therefore, the present proof-of-concept study examined whether ERA can be improved by a single session of a computerized training in AN, and whether this has short-term effects on eating disorder symptoms.

A meta-analysis of the relationship between emotion recognition ability and intelligence.

The ability to recognise others' emotions from nonverbal cues (emotion recognition ability, ERA) is measured with performance-based tests and has many positive correlates. Although researchers have long proposed that ERA is related to general mental ability or intelligence, a comprehensive analysis of this relationship is lacking. For instance, it remains unknown whether the magnitude of the association varies by intelligence type, ERA test features, as well as demographic variables.

The Geneva Emotional Competence Test (GECo): An ability measure of workplace emotional intelligence.

Emotional intelligence (EI) has been frequently studied as a predictor of work criteria, but disparate approaches to defining and measuring EI have produced rather inconsistent findings. The conceptualization of EI as an ability to be measured with performance-based tests is by many considered the most appropriate approach, but only few tests developed in this tradition exist, and none of them is designed to specifically assess EI in the workplace. The present research introduces the Geneva Emotional Competence test (GECo)-a new ability EI test measuring emotion recognition (assessed using video clips of actors), emotion understanding, emotion regulation in oneself, and emotion management in others (all assessed with situational judgment items of work-related scenarios).

The nomological network of emotion knowledge and emotion understanding in adults: evidence from two new performance-based tests.

Emotion understanding, which can broadly be defined as expertise in the meaning of emotion, is a core component of emotional intelligence and facilitates better intra- and interpersonal outcomes. However, to date only very few standard tests to measure emotion understanding in healthy adults exist. Here, we present two new performance-based tests that were developed and are scored based on componential emotion theory and large-scale cross-cultural empirical findings.

Intelligence and Sensory Sensitivity as Predictors of Emotion Recognition Ability.

The ability to recognize emotions from nonverbal cues (emotion recognition ability, ERA) is a core component of emotional intelligence, which has recently been conceptualized as a second-stratum factor of intelligence (MacCann et al., 2014). However, only few studies have empirically investigated the link between ERA, intelligence, and other mental abilities.

Amygdala structure and core dimensions of the affective personality.

While biological models of human personality propose that socio-affective traits and skills are rooted in the structure of the amygdala, empirical evidence remains sparse and inconsistent. Here, we used a comprehensive assessment of the affective personality and tested its association with global, local, and laterality measures of the amygdala structure. Results revealed three broad dimensions of the affective personality that were differentially related to bilateral amygdala structures.

Introducing a short version of the Geneva Emotion Recognition Test (GERT-S): Psychometric properties and construct validation.

The ability to accurately interpret others' emotional expressions in the face, voice, and body is a crucial component of successful social functioning and has been shown to predict better outcomes in private and professional life. To date, emotion recognition ability (ERA) has mostly been measured with tests that heavily rely on static pictures of the face and on few emotions, restricting their content validity. Recently, Schlegel, Grandjean, and Scherer (Psychological Assessment, 26, 666-672, 2014) published a new test that measures ERA in a more comprehensive fashion, by (1) including a wide range of 14 positive and negative emotions and (2) using video clips with sound that simultaneously present facial, vocal, and bodily emotional cues.