Publications by authors named "Katja R Wiedemann"
Article Synopsis
- Schistosomiasis, a parasitic infection affecting over 200 million people, primarily causes liver-related morbidity through its eggs rather than adult worms.
- Research methods involved advanced imaging and biochemical techniques on hamster models and human cell lines, validating findings with human biopsies.
- The study found that the infection leads to lipid and glycogen depletion in the liver, with parasites reprogramming host metabolism, resulting in oxidative stress and DNA damage, indicating a severe impact on liver cells regardless of the immune response.
Schistosomiasis, caused by the human parasite Schistosoma mansoni, is one of the WHO-listed neglected tropical diseases (NTDs), and it has severe impact on morbidity and mortality, especially in Africa. Not only the adult worms but also their eggs are responsible for health problems. Up to 50% of the eggs produced by the female worms are not excreted with the feces but are trapped in the host tissue, such as the liver, where they provoke immune responses and a change in the lipid profile.
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