Enantiospecific ketoprofen concentrations in plasma after oral and intramuscular administration in growing pigs.

Background: Ketoprofen is a non-steroidal anti-inflammatory drug which has been widely used for domestic animals. Orally administered racemic ketoprofen has been reported to be absorbed well in pigs, and bioavailability was almost complete. The objectives of this study were to analyze R- and S-ketoprofen concentrations in plasma after oral (PO) and intra muscular (IM) routes of administration, and to assess the relative bioavailability of racemic ketoprofen for both enantiomers between those routes of administration in growing pigs.

Oral ketoprofen is effective in the treatment of non-infectious lameness in sows.

The efficacy of ketoprofen in the treatment of non-infectious lameness in sows was examined in a double-blinded study. Two dose rates of oral ketoprofen were compared to placebo treatment over five consecutive days. Lameness was assessed with a five-grade scoring system prior to and on the last day of the treatment.

Evaluation of bioequivalence after oral, intramuscular, and intravenous administration of racemic ketoprofen in pigs.

Objective: To assess bioequivalence after oral, IM, and IV administration of racemic ketoprofen in pigs and to investigate the bioavailability after oral and IM administration.

Animals: 8 crossbred pigs.

Procedures: Each pig received 4 treatments in a randomized crossover design, with a 6-day washout period.