Publications by authors named "Katja Kirschbaum"
Detection of trace amounts of allergens is essential for correct labeling of food products by the food industry. PCR-based detection methods currently used for this purpose are targeting sequences of DNA present in the cell nucleus. In addition to nuclear DNA, a substantial amount of mitochondrial DNA (mtDNA) copies are present in the cytoplasm of eukaryotic cells.
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- - FGFRs play a crucial role in processes like cell movement, growth, and survival, and a new connection between FGFR1 and the cell adhesion molecule neurofascin has been discovered, particularly affecting neurite growth.
- - The study found that the embryonal neurofascin isoform NF166 can interact with FGFR1, promoting neurite outgrowth, while the adult isoform NF186 cannot due to structural differences.
- - The activation of FGFR1 by neurofascin depends mainly on its cytosolic domain, where specific serine residues are key for promoting neurite outgrowth, indicating different roles for the protein’s extracellular and intracellular regions during development.