The clinical effectiveness and cost effectiveness of clozapine for inpatients with severe borderline personality disorder (CALMED study): a randomised placebo-controlled trial.

Background: Data from case series suggest that clozapine may benefit inpatients with borderline personality disorder (BPD), but randomised trials have not been conducted.

Methods: Multicentre, double-blind, placebo-controlled trial. We aimed to recruit 222 inpatients with severe BPD aged 18 or over, who had failed to respond to other antipsychotic medications.

Experiences of women in secure care who have been prescribed clozapine for borderline personality disorder.

Background: Clozapine is an atypical antipsychotic medicine which can cause significant side-effects. It is often prescribed off-license in severe cases of borderline personality disorder contrary to national treatment guidelines. Little is known about the experiences of those who take clozapine for borderline personality disorder.

A case series of clozapine for borderline personality disorder.

Background: Borderline personality disorder (BPD) is a common, debilitating disorder for which the evidence base for treatment is modest. This case series aimed to explore preliminary evidence of clozapine's effectiveness for patients with severe BPD.

Methods: We examined the case notes of 22 female inpatients with a primary diagnosis of BPD who had started treatment with clozapine.

The prevalence of personality disorder, its comorbidity with mental state disorders, and its clinical significance in community mental health teams.

Background: Personality status is seldom assessed in community mental health teams except at a rudimentary level. This study challenges the assumption that this policy is either prudent or wise.

Aims: To measure the prevalence of personality disorder within community mental health teams and to investigate its relationship to mental state disorders and overall pathology.