Publications by authors named "Katie Yeung"

Article Synopsis
  • Heavy menstrual bleeding (HMB) significantly impacts quality of life, and many affected individuals receive inadequate management from healthcare providers.
  • This systematic review analyzed various studies to determine the prevalence of HMB causes and the effectiveness of diagnostic methods, focusing on premenopausal patients.
  • Findings revealed that bleeding disorders are common in HMB cases, particularly in adolescents, emphasizing the need for thorough investigation based on age and underlying conditions.
View Article and Find Full Text PDF

Background: Lichen Planus (LP) is a dermatological disorder characterized by violaceous papules that affect the cutaneous region, nails, scalp, and mucous membranes. Current molecular and clinical studies point to the Janus Kinase-signal transducer and activator of transcription (JAK-STAT) pathway as a potential effector of LP pathology.

Objective: This systematic review summarizes the current reported literature outcomes for patients receiving JAK inhibitors to treat LP.

View Article and Find Full Text PDF
Article Synopsis
  • Transfusion Camp is a 5-day educational program aimed at improving transfusion medicine knowledge among trainees from Canada and beyond, with a focus on its impact on clinical practice.
  • A retrospective analysis of surveys from 2018-2021 showed that 68% of participants felt the Camp positively influenced their practice, climbing to 83% by the end of the program, with key areas of impact including transfusion indications and risk management.
  • The results suggest that Transfusion Camp is an effective teaching method, with greater reported benefits in more advanced trainees (especially PGY-4+) and highlights areas for future curriculum improvement.
View Article and Find Full Text PDF

Objective: To provide recommendations for management of patients presenting with elevated self-administered bleeding assessment tool (Self-BAT) scores or other bleeding symptoms in a primary care setting.

Sources Of Information: Primary research sources, clinical review articles, and interviews with research staff, hematologists, and family physicians were used to create the poster tools and reference guide resources.

Main Message: Recommendations to manage a patient with an elevated Self-BAT score or other bleeding symptoms include reviewing the results of the Self-BAT to clarify relevant symptoms, performing initial diagnostic laboratory tests, and doing basic symptom management.

View Article and Find Full Text PDF

Excessive intake of retinoic acids (RAs) and the oxidative metabolites, 4-oxo-RAs, can lead to abnormal morphological development in animals. This study investigated spatiotemporal variations of concentrations and compositions of these compounds in Hong Kong's seawater and during algal blooms. Total concentrations of the studied compounds in seawater were up to 0.

View Article and Find Full Text PDF

Being a class of vitamin A's main derivatives, retinoic acids (RAs) are important to animals' growth and development. Previous studies demonstrated that exposure of excessive amounts of RAs would lead to malformation and abnormal development in aquatic animals such as amphibians and fishes. Currently, there are only limited toxicity data of RAs available for freshwater species, while those for marine species are seriously lacking.

View Article and Find Full Text PDF

Sewage treatment plants (STPs) are important in densely populated megacities like Hong Kong to control the release of harmful pollutants from households and industries into the receiving water bodies and maintain water quality for supporting various beneficial uses. This study investigated the occurrence of the teratogenic retinoic acids (RAs) and their oxidative metabolites in sewage and sludge of six selected STPs that treat about 87% of all sewage in Hong Kong annually, and compared the removal efficiencies of these compounds from sewage between two major sewage treatment processes, i.e.

View Article and Find Full Text PDF

Water quality guidelines and ecological risk assessment of chemical substances like nickel (Ni) in tropical regions such as South East Asia and Melanesia are often based on temperate information as a result of fewer Ni ecotoxicity data available for tropical species. This leaves an unknown margin of uncertainty in the risk assessment in the tropics. In order to fill this data gap, this study was designed to conduct standard toxicity tests on Ni with two freshwater species (acute tests) and three marine species (acute and chronic tests) originated from tropical Hong Kong.

View Article and Find Full Text PDF

Application of larvicidal oil (LO) is the most common practice in Hong Kong to control mosquitos, and hence prevent mosquito-borne diseases and protect human health. Globally, this study represented the first comprehensive assessment of toxicity and risk posed by LO to marine organisms. We found concentrations of LO ranged from 0.

View Article and Find Full Text PDF

Environmental and human health challenges are pronounced in Asia, an exceptionally diverse and complex region where influences of global megatrends are extensive and numerous stresses to environmental quality exist. Identifying priorities necessary to engage grand challenges can be facilitated through horizon scanning exercises, and to this end we identified and examined 23 priority research questions needed to advance toward more sustainable environmental quality in Asia, as part of the Global Horizon Scanning Project. Advances in environmental toxicology, environmental chemistry, biological monitoring, and risk-assessment methodologies are necessary to address the adverse impacts of environmental stressors on ecosystem services and biodiversity, with Asia being home to numerous biodiversity hotspots.

View Article and Find Full Text PDF

In animals, retinoic acids (RAs), one of the main derivatives of vitamin A, are crucial for a variety of physiological processes. RAs, including all-trans-RA, 9-cis-RA, 13-cis-RA, and their corresponding metabolites (i.e.

View Article and Find Full Text PDF

In early August 2017, a serious palm stearin pollution accident occurred in the Pearl River Estuary, South China. While there were already several palm oil related spills around the world, the ecological effects and risks of such accidents to coastal marine environments remain largely unknown. In this study, we found that all seawater and sediment samples collected from six coastal sites were heavily contaminated by palm stearin within 1 week of the accident, and their levels significantly decreased to preaccident levels after four months.

View Article and Find Full Text PDF

Substantial production and wide applications of engineered nanomaterials (ENMs) have raised concerns over their potential influences on the environment and humans. However, regulations of products containing ENMs are scarce, even in countries with the greatest volume of ENMs produced, such as the United States and China. After a comprehensive review of life cycles of ENMs, five major challenges to regulators posed by ENMs are proposed in this review: (a) ENMs exhibit variable physicochemical characteristics, which makes them difficult for regulators to establish regulatory definition; (b) Due to diverse sources and transport pathways for ENMs, it is difficult to monitor or predict their fates in the environment; (c) There is a lack of reliable techniques for quantifying exposures to ENMs; (d) Because of diverse intrinsic properties of ENMs and dynamic environmental conditions, it is difficult to predict bioavailability of ENMs on wildlife and the environment; and (e) There are knowledge gaps in toxicity and toxic mechanisms of ENMs from which to predict their hazards.

View Article and Find Full Text PDF