Randomized controlled trial of a breath-actuated nebulizer in pediatric asthma patients in the emergency department.

Background: Bronchodilator treatment for asthma can be provided with various aerosol-generating devices and methods. There have been no randomized trials of a breath-actuated nebulizer versus continuous 1-hour nebulization and/or small-volume constant-output nebulizer in pediatric asthma patients.

Methods: We conducted a randomized study of one-time albuterol treatment with the AeroEclipse breath-actuated nebulizer versus standard therapy (single treatment via small-volume nebulizer or 1-hour of continuous nebulized albuterol) in pediatric asthma patients in the emergency department.

Efficacy and safety of lung recruitment in pediatric patients with acute lung injury.

Objective: To assess the safety and efficacy of a recruitment maneuver, the Open Lung Tool, in pediatric patients with acute lung injury and acute respiratory distress syndrome.

Design: Prospective cohort study using a repeated-measures design.

Setting: Pediatric intensive care unit at an urban tertiary children's hospital.