Determining Social Needs for Pediatric Patients in a Sioux Falls Pediatric Clinic.

Introduction: Social adversities such as financial insecurity, poor access to healthcare, shortage of food, and housing concerns can significantly impact health, especially for pediatric patients. The American Academy of Pediatrics recommends that pediatricians address social risks and provide interventions. This is a study where a social needs assessment screening tool was implemented at a general pediatrics clinic in Sioux Falls, South Dakota, to determine the needs of patients in the community with secondary outcomes evaluating ethnic differences in social needs.

Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated () Gene are Associated with High and Moderate Risks for Multiple Cancers.

Pathogenic variants (PVs) in are relatively common, but the scope and magnitude of risk remains uncertain. This study aimed to estimate PV cancer risks independent of family cancer history. This analysis included patients referred for hereditary cancer testing with a multi-gene panel ( = 627,742).

Prevalence of Pathogenic Variants in Cancer Susceptibility Genes Among Women With Postmenopausal Breast Cancer.

This study uses Women’s Health Initiative data to compare the prevalence of pathogenic variants (PVs) in breast cancer susceptibility genes in postmenopausal women with vs without breast cancer to guide decisions about who should undergo PV testing.

High risk of breast cancer in women with biallelic pathogenic variants in CHEK2.

Purpose: Compared to breast cancer risk genes such as BRCA2, ATM, PALB2, and NBN, no defined phenotype is currently associated with biallelic pathogenic variants (PVs) in CHEK2. This study compared the prevalence of breast and other cancers in women with monoallelic and biallelic CHEK2 PVs.

Methods: CHEK2 PV carriers were identified through commercial hereditary cancer panel testing (09/2013-07/2019).

Endogenous methicillin-resistant Staphylococcus aureus endophthalmitis after leg trauma.

We present a case of endogenous endophthalmitis in a 13-year-old boy with methicillin-resistant Staphylococcus aureus sepsis. The patient underwent magnetic resonance imaging of the brain after intermittent anisocoria was noted on examination, leading to a diagnosis of endophthalmitis with a chorodial abscess.

Respiratory pathogen testing.

Respiratory tract infections (RTIs) are common in the pediatric population and contribute to a large portion of health care expenditure. A variety of modalities currently exist for testing for these pathogens in patients and as technology advances new, more efficient and specific tests are becoming available. This article reviews the most common causes of respiratory tract infections and the available testing modalities.

Spontaneous pneumomediastinum with subcutaneous emphysema: report of two pediatric cases.

We present two children diagnosed with spontaneous pneumomediastinum. The first case is a 9-year-old male who developed neck pain with a history of poorly controlled asthma and recently diagnosed right middle lobe pneumonia. The second case is a 14-year-old male who developed chest pain with a history of cough and congestion for four days.

Effectiveness of intradiscal electrothermal therapy in increasing function and reducing chronic low back pain in selected patients.

Intradiscal electrothermal therapy (IDET) is a percutaneous intervention used to treat pain from internal disc disruption. We reviewed the patients who underwent this procedure in our practice. We found, in an appropriately selected group of patients, an increase in sitting and standing tolerances and a decrease in pain levels.