Evaluation of thiamine for the prevention of ifosfamide-induced encephalopathy.

Study Objective: To determine whether thiamine prophylaxis decreases the incidence of ifosfamide-induced encephalopathy in patients receiving ifosfamide for the treatment of lymphoma.

Design: Retrospective, multi-center, cohort study.

Patients: A total of 73 patients who received 187 total cycles of ifosfamide, carboplatin, and etoposide chemotherapy for the treatment of lymphoma were included in this study.