Do fatigue and depression have a bivariate association with device-measured physical activity behavior in persons with multiple sclerosis?

Purpose: This study examined the bivariate association between fatigue and depression symptoms and physical activity behavior in persons with multiple sclerosis (MS).

Methods: The sample of adults with MS completed the Fatigue Severity Scale (FSS) and the Hospital Anxiety and Depression Scale (HADS) and wore a waist mounted accelerometer during waking hours for 7 days. We categorized participants as having elevated fatigue and depression based on cut-points for the FSS (i.

Proteomic biomarkers of Kleine-Levin syndrome.

Study Objectives: Kleine-Levin syndrome (KLS) is characterized by relapsing-remitting episodes of hypersomnia, cognitive impairment, and behavioral disturbances. We quantified cerebrospinal fluid (CSF) and serum proteins in KLS cases and controls.

Methods: SomaScan was used to profile 1133 CSF proteins in 30 KLS cases and 134 controls, while 1109 serum proteins were profiled in serum from 26 cases and 65 controls.

The genetic etiology of periodic limb movement in sleep.

Study Objectives: Periodic limb movement in sleep is a common sleep phenotype characterized by repetitive leg movements that occur during or before sleep. We conducted a genome-wide association study (GWAS) of periodic limb movements in sleep (PLMS) using a joint analysis (i.e.

Perceived injustice in multiple sclerosis: An initial, exploratory study.

Purpose/objective: The current study represents an initial examination of condition-related perceived injustice (PI) in multiple sclerosis (MS) by examining (a) the structural validity and reliability of the Injustice Experience Questionnaire (IEQ) scores and (b) the associations between IEQ scores and scores from measures of anger, pain, depression, anxiety, fatigue, disability, health-related quality of life (HRQOL), physical activity, and sedentary behavior. Research Method/Design: Persons with MS were recruited through the distribution of letters to a random sample of 1,000 persons from the North American Research Committee on MS registry. Participants who completed the IEQ (N = 139) were included in this analysis.

Walking and cognitive performance in adults with multiple sclerosis: Do age and fatigability matter?

Background: Co-occurring walking and cognitive performance deficits are debilitating consequences of multiple sclerosis (MS) that worsen with age. However, it is unknown if fatigability influences such age-related worsening of walking and cognitive performance.

Objective: This cross-sectional study examined possible age-related differences in walking-related motor fatigability (incremental six-minute-walk (6MW) performance) and cognitive fatigability (incremental Symbol Digit Modalities Test (SDMT) performance) in adults with MS.

Step-rate threshold for physical activity intensity in Parkinson's disease.

Objectives: To examine the relationship between step-rate and energy expenditure during treadmill walking in persons with PD and then further develop a step-rate cut-point for moderate-to-vigorous physical activity (MVPA) for persons with PD.

Materials And Methods: The sample consisted of 30 persons with mild-to-moderate PD and 30 controls matched by age and sex. Participants performed a 6-minute bout of over-ground walking at comfortable speed, and then completed three, 6-minute bouts of treadmill walking at 13.

Quantitative Synthesis of Timed 25-Foot Walk Performance in Multiple Sclerosis.

Objective: To provide a meta-analysis of articles that have included the timed 25-foot walk (T25FW) in persons with multiple sclerosis (MS), quantify differences in T25FW scores between those with MS and controls without MS, and quantify differences between categories of disability status and clinical disease courses within MS.

Data Sources: The literature search was conducted using 4 databases (Google Scholar, PubMed, Cumulative Index to Nursing and Allied Health, EBSCO Host). We searched reference lists of published articles to identify additional articles.

Does restless legs syndrome impact cognitive function via sleep quality in adults with Parkinson's disease?

Restless legs syndrome (RLS) is a sleep disorder that results in sleep dysfunction. Sleep disruption can have profound negative consequences in adults with Parkinson's disease (PD), potentially including cognitive dysfunction. This study examined the relationships among RLS, cognition, and sleep quality in persons with PD.

Self-efficacy and walking performance across the lifespan among adults with multiple sclerosis.

We examined associations between self-efficacy and walking mobility across the lifespan in multiple sclerosis (MS). This study included 39 young, 44 middle-aged and 41 older adults with MS who completed the Six-Minute Walk (6MW), Timed 25-foot Walk (T25FW), MS Walking Scale-12 (MSWS-12) and MS Self-efficacy Scale. Self-efficacy for function explained 45 and 48% of variance in MSWS-12 scores for young and older adults with MS, respectively; 13, 29 and 23% of variance in T25FW for young, middle-aged and older adults, respectively; and 28, 31 and 28% of variance in 6MW for young, middle-aged and older adults with MS, respectively.

Validity of sitting time scores from the International Physical Activity Questionnaire-Short Form in multiple sclerosis.

Purpose: The current study examined the validity of scores from the sitting time item on the International Physical Activity Questionnaire-Short Form (IPAQ-SF) in a sample of persons with multiple sclerosis (MS).

Method: Persons with MS were recruited through the distribution of printed letters to a random sample of 1,000 persons from the North American Research Committee on MS registry. Two hundred ninety-five persons with MS were interested and volunteered to wear an ActiGraph accelerometer for a 7-day period and complete a battery of questionnaires that included the IPAQ-SF and Godin Leisure-Time Exercise Questionnaire over this period of time.

Sociodemographic and clinical correlates of device-measured sedentary behaviour in multiple sclerosis.

Purpose: This study examined sociodemographic and clinical variables as correlates of device-measured volume and pattern of sedentary behaviour in persons with multiple sclerosis (MS).

Materials And Methods: Participants were recruited through a standardised invitation letter distributed among 1000 persons randomly selected from the North American Research Committee on MS registry. Those who volunteered wore an accelerometer for 7 d and provided sociodemographic and clinical information.

Self-Regulatory Strategies as Correlates of Physical Activity Behavior in Persons With Multiple Sclerosis.

Objective: To examine self-regulation strategies as correlates of physical activity in persons with multiple sclerosis (MS).

Design: Cross-sectional, or survey, study.

Setting: University-based research laboratory.

Physical Activity, Sedentary Behavior, and Physical Function in Older Adults With Multiple Sclerosis.

Older adults with multiple sclerosis (MS) experience the combined effects of aging and a chronic, disabling neurological disease on physical activity, sedentary behavior, and physical function. This study examined associations among light and moderate-to-vigorous physical activity (LPA and MVPA), sedentary behavior, and physical function in older adults with MS. Forty older adults with MS (median age = 60 years) who had a median Expanded Disability Status Scale score of 4.