BβArg448Lys polymorphism is associated with altered fibrin clot structure and fibrinolysis in type 2 diabetes.

Both type 2 diabetes (T2DM) and Bβ448Lys variant of fibrinogen are associated with dense fibrin clots, impaired fibrinolysis and increased cardiovascular risk. It was our objective to investigate whether BβArg448Lys adds to vascular risk by modulating fibrin network structure and/or fibrinolysis in diabetes. The primary aim was to study effects of BβArg448Lys on fibrin network characteristics in T2DM.

Effect of food on the pharmacokinetics of multiple-dose oral voriconazole.

Aims: Voriconazole is a new triazole antifungal agent with activity against a range of clinically important and emerging pathogens. This study determined the effect of food on the pharmacokinetics of voriconazole in healthy volunteers.

Methods: This was an open, randomized, two-way crossover, multiple-dose study in male volunteers.

Voriconazole, a novel wide-spectrum triazole: oral pharmacokinetics and safety.

Aims: Voriconazole is a potent new triazole with broad-spectrum antifungal activity against clinically significant and emerging pathogens. The present study evaluated the safety, toleration, and pharmacokinetics of oral voriconazole after single and multiple dosing.

Methods: Sixty-four healthy subjects were randomized to receive treatment and 56 completed the study.

The pharmacokinetics and safety of intravenous voriconazole - a novel wide-spectrum antifungal agent.

Aims: Voriconazole is a new triazole with broad-spectrum antifungal activity against clinically significant and emerging pathogens. These studies evaluated the pharmacokinetics and safety of intravenous voriconazole in healthy male volunteers.

Methods: Two single-blind, placebo-controlled studies were conducted.