Reproductive Ageing: Declining translational capacity as a potential driver for oocyte meiotic instability.

In Brief: This point of view article focuses on the potential contribution of defects in protein synthesis (translation) to the incidence of oocyte meiotic failure. We discuss the potential cause of diminished oocyte translation during aging and the impact of these deficits on the function of the meiotic spindle.

Abstract: Errors during female meiosis lead to embryonic aneuploidy and miscarriage and occur with increasing frequency during aging.

Mechanism of secretion of TcpF by the toxin-coregulated pilus.

Many bacteria possess dynamic filaments called Type IV pili (T4P) that perform diverse functions in colonization and dissemination, including host cell adhesion, DNA uptake, and secretion of protein substrates-exoproteins-from the periplasm to the extracellular space. The toxin-coregulated pilus (TCP) and the enterotoxigenic  CFA/III pilus each mediates export of a single exoprotein, TcpF and CofJ, respectively. Here, we show that the disordered N-terminal segment of mature TcpF is the export signal (ES) recognized by TCP.

Approximations in English language arts: Scaffolding a shared teaching practice.

Recent research highlights the importance of providing teacher candidates with opportunities to approximate practice. Less attention focuses on tools teacher educators use within and surrounding approximations to focus candidates' attention on features of practice. This multi-case study investigates how three teacher educators use different approximations in ways that strategically reduce the complexity of learning to teach and scaffold the development of practice.