Paraneoplastic hypercalcemia in a canine patient with a mandibular salivary carcinoma.

Objective: To describe a novel presentation of paraneoplastic hypercalcemia caused by a canine salivary carcinoma.

Animal: A 6-year-old intact male Husky with hypercalcemia and a spontaneous salivary carcinoma, stage III.

Clinical Presentation, Progression, And Procedures: The dog presented with polyuria, polydipsia, and hypercalcemia.

Evaluation of a multiagent chemotherapy protocol combining vincristine, cyclophosphamide, mitoxantrone and prednisolone (CMOP) for treatment of feline intermediate-large cell lymphoma.

Objectives: The aim of this study was to determine response rates, median progression-free intervals (PFIs) and median survival times (MSTs) for cats with intermediate-large cell lymphoma treated with a vincristine, cyclophosphamide, mitoxantrone and prednisolone (CMOP) protocol. A secondary objective was to determine the tolerability of mitoxantrone used within this multiagent protocol.

Methods: The medical records of 31 cats treated at a single institution between 2009 and 2022 were reviewed to identify suitable cases.

Preliminary assessment of serum clusterin as a potential biomarker for canine lymphoma.

Clusterin (CLU), also known as apolipoprotein J, is a widely expressed, heterodimeric, glycoprotein, important in tumourigenesis, apoptosis and immunoregulation. In humans, CLU expression has been associated with anaplastic large cell and Hodgkin's lymphoma. In this study, serum CLU levels in dogs with multicentric lymphoma (MLSA) were compared with healthy control dogs, using both western blot and enzyme-linked immunosorbent assay (ELISA).

Spinal extradural T-cell lymphoma with paraneoplastic hypereosinophilia in a dog: clinicopathological features, treatment, and outcome.

Spinal lymphoma is a rare manifestation of a common canine hematopoietic neoplasia. Description of treatment, outcome, and MRI features are scarce. The latter can be heterogeneous, stressing the importance of lesion excision and analysis.