Publications by authors named "Katie A Hietala"

Sindbis virus (SIN) is a mosquito-transmitted animal RNA virus. We previously reported that SIN genomes lacking a canonical 19 nt 3'CSE undergo novel repair processes in BHK cells to generate a library of stable atypical SIN genomes with non-canonical 3'A/U-rich elements (NC3AREs) adjacent to the 3' poly(A) tail [1]. To determine the stability and evolutionary pressures on the SIN genomes with NC3AREs to regain a 3'CSE, five representative SIN isolates and a wild type SIN were tested in newborn mice.

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Microbial growth can be described using models derived by differential equations, but available mathematical models have yet to adequately describe lag phase related cell growth or cell mortality in response to chemical toxicity. Lag phase cell behavior, however, dictates the onset of exponential growth and the number of actively growing cells available to initiate exponential growth, important factors in the success of remediation efforts. In this study, a five-parameter polynomial ratio (PR) model was used to characterize the growth, from lag through stationary phase, of the yeast Saccharomyces cerevisiae in response to cadmium toxicity.

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