Evaluation of the effectiveness of a wearable cardioverter defibrillator detection algorithm.

Background: Wearable cardioverter defibrillators (WCDs) provide protection from sudden cardiac death. The efficacy of a WCD detection algorithm has not been reported outside of clinical trial.

Methods: The efficacy of the algorithm was reviewed through a retrospective analysis of appropriate shocks, inappropriate shocks, and arrhythmia detections during a 1-year period.

Identification and association analysis of single nucleotide polymorphisms in the human noggin (NOG) gene and osteoporosis phenotypes.

Noggin, an extracellular bone morphogenic protein (BMP) antagonist, blocks BMP signaling and decreases osteoblastogenesis. The purpose of this study was to identify novel sequence variations in the human noggin gene and to perform association analyses of these variations with phenotypes related to osteoporosis. Novel single nucleotide polymorphisms (SNPs) were identified by resequencing 7 kb of the noggin gene region in 24 randomly selected Afro-Caribbean men without regard to their bone mineral density (BMD) level.