Association between serum levels of inflammatory mediators and periodontitis severity in people with down syndrome.

Evidence suggests that individuals with Down syndrome (DS) have a high prevalence of periodontal disease (PD). Factors such as muscular hypotonia, macroglossia, intellectual deficits, and reduced motor coordination, often combined with inadequate dietary habits, contribute to the development of PD. Additionally, a compromised immune response may explain the altered inflammatory profile that affects the systemic and oral health of this population.