Publications by authors named "Katia Conceicao Machado"
Agathisflavone (AGF) is a biflavonoid with a number of important biological and pharmacological activities, such as antioxidant, antimicrobial, and neuroprotective effects. However, its toxicological effects have not been fully investigated. Accordingly, the aim of this study was to investigate the toxicological effects of AGF in mice.
View Article and Find Full Text PDFEffect of Diets, Familial History, and Alternative Therapies on Genomic Instability of Breast Cancer Patients.
Appl Biochem Biotechnol
May 2019
This study evaluates a correlation between family history, micronutrients intake, and alternative therapies with genetic instability, before and during breast cancer treatment. For this study, a total of 150 women were selected. Among those, 50 women were breast cancer patients on chemotherapy, while 50 breast cancer patients were on radiotherapy, and 50 were healthy females.
View Article and Find Full Text PDFPersistent Increased Frequency of Genomic Instability in Women Diagnosed with Breast Cancer: Before, during, and after Treatments.
Oxid Med Cell Longev
October 2018
Article Synopsis
- - This study assessed DNA damage in breast cancer patients before and after treatment using the Comet assay and the micronucleus test in different cell types.
- - 100 women with breast cancer were compared to a control group of 50 women without cancer, revealing a significant increase in DNA damage and micronuclei in cancer patients throughout their treatment.
- - Findings indicate that breast cancer patients experience ongoing DNA lesions due to the cancer itself and treatment side effects, which tend to worsen after radiotherapy.
Correlations between Risk Factors for Breast Cancer and Genetic Instability in Cancer Patients-A Clinical Perspective Study.
Front Genet
February 2018
Article Synopsis
- Molecular epidemiological studies reveal that genetic instability from DNA damage plays a key role in breast cancer diagnosis and treatment outcomes.
- This study analyzed 150 individuals, including breast cancer patients undergoing chemotherapy and radiotherapy, to assess the impact of sociocultural and lifestyle factors on genetic instability.
- Findings indicate that older age, smoking, and exposure to ionizing radiation contribute to higher levels of DNA damage, suggesting that these risk factors may exacerbate genetic instability in non-cancerous cells during treatment.
β-caryophyllene is a food additive that is found in food plants and has broad pharmacological potential. However, little toxicological information has been reported and its use is based on the fact that this bicyclic sesquiterpene is daily consumed as a plant food in much larger quantities than as a food additive. Thus, this study evaluated acute (14-day) and repeated-dose (28 days) oral β-caryophyllene toxicity in female Swiss mice analyzing changes in body weight, food intake, water intake, hematological and biochemical parameters, organ weight after necropsy, oxidative stress markers and histopathology of various tissues.
View Article and Find Full Text PDFPhytol (PYT) is a diterpenoid having important biological activity. However, it is a water non-soluble compound. This study aims to prepare PYT nanoemulsion (PNE) and evaluation of toxic, cytotoxic and genotoxic activities of PYT and PNE.
View Article and Find Full Text PDFThis study aims to review phytol (PYT), through published articles, periodicals, magazines and patents, which were retrieved from the PM, SD, WS, SP; DII, WIPO, CIPO, USPTO and INPI databases. Among the 149 articles and 62 patents, 27.52% articles and 87.
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