Identification of Piecemeal Degranulation and Vesicular Transport of MBP-1 in Liver-Infiltrating Mouse Eosinophils During Acute Experimental Infection.

Eosinophils have been long associated with helminthic infections, although their functions in these diseases remain unclear. During schistosomiasis caused by the trematode , eosinophils are specifically recruited and migrate to sites of granulomatous responses where they degranulate. However, little is known about the mechanisms of eosinophil secretion during this disease.

Histological assessment of granulomas in natural and experimental Schistosoma mansoni infections using whole slide imaging.

The pathology of schistosomiasis mansoni, a neglected tropical disease of great clinical and socioeconomic importance, results from the parasite eggs that become trapped in host tissues, particularly in the liver and intestines. Continuous antigenic stimulation from these eggs leads to recruitment of inflammatory cells to the sites of infection with formation of periovular granulomas. These complex structures have variable size and composition and are the most striking histopathological feature of schistosomiasis mansoni.

Expression and subcellular localization of the Qa-SNARE syntaxin17 in human eosinophils.

Background: SNARE members mediate membrane fusion during intracellular trafficking underlying innate and adaptive immune responses by different cells. However, little is known about the expression and function of these proteins in human eosinophils, cells involved in allergic, inflammatory and immunoregulatory responses. Here, we investigate the expression and distribution of the Qa-SNARE syntaxin17 (STX17) within human eosinophils isolated from the peripheral blood.

Human Eosinophil Leukocytes Express Protein Disulfide Isomerase in Secretory Granules and Vesicles: Ultrastructural Studies.

Protein disulfide isomerase (PDI) has fundamental roles in the oxidative folding of proteins in the endoplasmic reticulum (ER) of eukaryotic cells. The study of this molecule has been attracting considerable attention due to its association with other cell functions and human diseases. In leukocytes, such as neutrophils, PDI is involved with cell adhesion, signaling and inflammation.

[Malaricide activity of the quercetin in Gallus gallus L., 1758 immunocompromised infected by Plasmodium (Bennettinia) juxtanucleare Versiani and Gomes, 1941].

The aim of this study was comparatively to evaluate the malaricide activity of the quercetin to the action of the chloroquine in Gallus gallus experimentally infected for Plasmodium juxtanucleare and immunocompromised. Thirty- four hens had been used, previously infected for P. juxtanucleare and immunocompromised by the administration of 26 mg/kg of metilprednisolon 40mg/ml in the pectoral muscle.