The use of real-world effectiveness measurements in clinical settings at Helsinki University Hospital: a systematic literature review.

Patient reported outcomes collected alongside clinical trials do not reflect real-world effectiveness (RWE). This review assessed the use of RWE measurements in routine clinical treatment and the instruments applied to collect that data. The RWE articles published from HUS (Helsinki University Hospital) were extracted from several databases.

Development and simultaneous application of multiple care protocols in critical care: a multicenter feasibility study.

Objective: To test the feasibility of and interactions among three software-driven critical care protocols.

Design: Prospective cohort study.

Setting: Intensive care units in six European and American university hospitals.