Publications by authors named "Kathy-Ann Cadogan"
Article Synopsis
- - The study aimed to create a patient-centered measurement tool to assess the burden of complex cryptoglandular fistulas (CCF) and the effectiveness of treatments, addressing a gap in existing evaluation methods.
- - Researchers conducted a literature review and interviews with colorectal surgeons and patients to gather insights on symptoms and life impacts related to CCF, using this information to develop a conceptual model and draft a CCF-specific patient-reported outcome measure (PROM).
- - The final PROM identifies ten key symptoms and eleven major impacts on patients' lives, including issues like pain, embarrassment, and mood disturbances, which were highlighted as significant by patients during interviews.
Purpose: Evaluate the safety profile of expanded allogeneic adipose-derived mesenchymal stem cell (eASC) for the treatment of severe community-acquired bacterial pneumonia (CABP).
Materials And Methods: Randomized, multicenter, double-blind, placebo-controlled, phase 1b/2a trial. Patients with severe CABP were enrolled to receive intravenous infusions of Cx611 or placebo.
Background: Community-acquired bacterial pneumonia (CABP) can lead to sepsis and is associated with high mortality rates in patients presenting with shock and/or respiratory failure and who require mechanical ventilation and admission to intensive care units, thus reflecting the limited effectiveness of current therapy. Preclinical studies support the efficacy of expanded allogeneic adipose-derived mesenchymal stem cells (eASCs) in the treatment of sepsis. In this study, we aim to test the safety, tolerability and efficacy of eASCs as adjunctive therapy in patients with severe CABP (sCABP).
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