Publications by authors named "Kathy Tian"
Neuromolecular Med
September 2017
Article Synopsis
- Previous studies show that LRP1 has mixed effects in Alzheimer's disease, helping clear beta-amyloid while also promoting its production.
- New research found that a mutation in LRP1 (LRP1-CT C4408R) can reduce beta-amyloid production and increase beneficial fragments of APP when co-expressed with mutant APP in cells.
- This mutation seems to slow down the process that leads to harmful amyloid production, suggesting it could be a potential target for developing treatments to slow Alzheimer's progression.
