Publications by authors named "Kathryn S Epilepsia"
Article Synopsis
- Metastatic castration-resistant prostate cancer is still incurable, despite recent treatments, and tumors show increased glycolysis as they progress.
- The study introduces BKIDC-1553, a new small-molecule compound that inhibits glycolysis specifically in prostate cancer cells without causing severe toxicity, and demonstrates promising results in preclinical models.
- BKIDC-1553 shows effective growth inhibition in various prostate cancer models and has safety and pharmacokinetic properties that suggest it’s ready for clinical trials to treat advanced prostate cancer.
Article Synopsis
- Metastatic castration-resistant prostate cancer remains largely untreatable, but this study focuses on a new small molecule, BKIDC-1553, that inhibits glycolysis in cancer cells without significant toxicity.
- Researchers tested BKIDC-1553 across various prostate cancer models and found it effectively inhibits cell proliferation and shows promising results in preclinical trials, comparable to existing treatments like enzalutamide.
- The findings suggest that BKIDC-1553 has the potential for safe use in human clinical trials, paving the way for new treatment options for advanced prostate cancer patients.
The appearance of constitutively active androgen receptor splice variants (AR-Vs) has been proposed as one of the causes of castration-resistant prostate cancer (CRPC). However, the underlying mechanism of AR-Vs in CRPC transcriptional regulation has not been defined. A distinct transcriptome enriched with cell cycle genes, e.
View Article and Find Full Text PDFAndrogen deprivation therapy remains the primary treatment modality for patients with metastatic prostate cancer but is uniformly marked by progression to castration-resistant prostate cancer (CRPC) after a period of regression. Continued activation of androgen receptor (AR) signaling is attributed as one of the most important mechanisms underlying failure of therapy. Recently, the discovery of constitutively active AR splice variants (AR-Vs) adds more credence to this idea.
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