Not all cholecystitis is created equal: Disparities contributing to ED presentation and failure of the outpatient algorithm.

Background: The majority of final surgical pathology (FSP) from both emergency department (ED) and outpatient clinic (OC) patients is chronic cholecystitis. We aimed to differentiate these presentations and identify disparities associated with ED utilization and OC failure.

Methods: Retrospective chart review of single institution ED and OC cholecystectomies for cholelithiasis.

IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway.

Resistance to androgen receptor (AR) targeting therapeutics in prostate cancer (PC) is a significant clinical problem. Mechanisms by which this is accomplished include AR amplification and expression of AR splice variants, demonstrating that AR remains a key therapeutic target in advanced disease. For the first time we show that IKBKE drives AR signalling in advanced PC.

Antiviral Medications, Part 1: Treating Herpes and Influenza Viruses.

The pharmacotherapeutic goal of treatment with antiviral medica- tions is to slow viral replication, treat current symptoms, reduce transmission, and shorten the course of the disease process. Medical-surgical nurses play an instrumental role in safe medica- tion administration and patient monitoring.

Development and validation of the Eating Pathology Symptoms Inventory (EPSI).

Many current measures of eating disorder (ED) symptoms have 1 or more serious limitations, such as inconsistent factor structures or poor discriminant validity. The goal of this study was to overcome these limitations through the development of a comprehensive multidimensional measure of eating pathology. An initial pool of 160 items was developed to assess 20 dimensions of eating pathology.

Gauging visibility: how female clerical workers manage work-related distress.

Our aim was to explain how female clerical workers manage work-related distress, using a feminist grounded theory method. Thirty-seven interviews were conducted with 24 female clerical workers. They engage in the process of gauging visibility to manage a recognition-vulnerability paradox.

Binding cooperativity in phage lambda is not sufficient to produce an effective switch.

In the wild-type phage lambda, binding of CI to O(R)2 helps polymerase bound to P(RM) transition from a closed to open complex. Activators on other promoters increase the polymerase-DNA binding energy, or affect both the binding energy and the closed-open transition probability. Using a validated mathematical model, we show that these two modes of upregulation have very different effects on the promoter function.

Qualitative teamwork issues and strategies: coordination through mutual adjustment.

Multidisciplinary research teams that include faculty, students, and volunteers can be challenging and enriching for all participants. Although such teams are becoming commonplace, minimal guidance is available about strategies to enhance team effectiveness. In this article, the authors highlight strategies to guide qualitative teamwork through coordination of team members and tasks based on mutual adjustment.

The etiology of white pox, a lethal disease of the Caribbean elkhorn coral, Acropora palmata.

Populations of the shallow-water Caribbean elkhorn coral, Acropora palmata, are being decimated by white pox disease, with losses of living cover in the Florida Keys typically in excess of 70%. The rate of tissue loss is rapid, averaging 2.5 cm2 x day(-1), and is greatest during periods of seasonally elevated temperature.