Publications by Kathryn Lorenz Sarachan | LitMetric

Publications by authors named "Kathryn Lorenz Sarachan"

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Structural basis for ubiquitin recognition by the Otu1 ovarian tumor domain protein.

Troy Eugene Messick Nathaniel Scott Russell Ayaka Jennifer Iwata Kathryn Lorenz Sarachan Ramin Shiekhattar

J Biol Chem

April 2008

Article Synopsis

* The study focuses on the yeast protein Otu1, which binds more effectively to polyubiquitin chains than to monoubiquitin and specifically hydrolyzes longer chains linked by Lys(48).
* Researchers determined the x-ray crystal structure of Otu1's OTU domain complexed with ubiquitin, uncovering a new method of ubiquitin recognition and variations in the papain protease catalytic site, shedding light on OTU proteins' function in ubiquitin processing.

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