Inositol Polyphosphate-5-Phosphatase K () Enhances Sprouting of Corticospinal Tract Axons after CNS Trauma.

Failure of CNS neurons to mount a significant growth response after trauma contributes to chronic functional deficits after spinal cord injury. Activator and repressor screening of embryonic cortical neurons and retinal ganglion cells and transcriptional profiling of developing CNS neurons harvested have identified several candidates that stimulate robust axon growth and Building on these studies, we sought to identify novel axon growth activators induced in the complex adult CNS environment We transcriptionally profiled intact sprouting adult corticospinal neurons (CSNs) after contralateral pyramidotomy (PyX) in nogo receptor-1 knock-out mice and found that intact CSNs were enriched in genes in the 3-phosphoinositide degradation pathway, including six 5-phosphatases. We explored whether inositol polyphosphate-5-phosphatase K () could enhance corticospinal tract (CST) axon growth in preclinical models of acute and chronic CNS trauma.