Publications by authors named "Kathryn K Joyce"
Article Synopsis
- Sleep disruption and Tau accumulation are linked to cognitive decline in Alzheimer's disease, but the relationship between them is not fully understood.
- In a study using PS19 mice, early-onset hyperarousal and selective sleep disruption were observed, with significant memory decline due to chronic sleep disruption occurring in males.
- Despite earlier hyperarousal in females, they showed more resilience in cognitive decline compared to males, indicating potential sex-specific differences in the effects of sleep disruption on cognitive health.
Pharmaceuticals (Basel)
February 2024
Article Synopsis
- Sleep disruption is common in aging and neurodegenerative diseases like Alzheimer's, contributing to cognitive decline and AD progression, making better sleep treatments necessary.
- Current sleep medications can increase the risk of AD, prompting researchers to explore alternatives like the endocannabinoid system and fatty acid amide hydrolase (FAAH) as potential sleep aids.
- While inhibiting FAAH showed short-term benefits for sleep in a model of Tauopathy, knockout studies indicated that completely disabling FAAH may not be beneficial for overall sleep health or cognitive function.
Article Synopsis
- Sleep disruption is linked to neurodegenerative diseases like Alzheimer's, where impaired synaptic processes may contribute to cognitive decline, particularly through Tau protein aggregation.
- A study using transgenic mice revealed that PS19 mice experience early loss of sleep during the dark phase, with females showing symptoms earlier than males.
- Although sleep disruption did not increase Tau pathology in the brain, chronic sleep loss was found to worsen spatial memory decline specifically in male mice.
