Team science competencies for clinical research professionals: A multileveled Delphi approach.

Background: The knowledge, skills, and abilities needed for clinical research professionals (CRPs) are described in the Joint Task Force (JTF) for Clinical Trial Competencies Framework as a basis for leveled educational programs, training curricula, and certification. There is a paucity of literature addressing team science competencies tailored to CRPs. Gaps in training, research, and education can restrict their capability to effectively contribute to team science.

Varieties of gratitude: Identifying patterns of emotional responses to positive experiences attributed to God, karma, and human benefactors.

Good fortune can be attributed to many sources, including other people, personal efforts, and various theistic and nontheistic supernatural forces (e.g., God, karma).

Expanding Understanding of Electrocochleography in Cochlear Implantation: Auditory Neuropathy Spectrum Disorder With Normal Pure Tone Average.

Objective: Describe the preoperative decision-making, intraoperative electrocochleographic (ECoG) findings, and outcome of cochlear implantation (CI) in a patient with auditory neuropathy spectrum disorder (ANSD) and normal pure-tone thresholds.

Patients: A 19-year-old with a history of hypoxic ischemic encephalopathy and seizures was referred for hearing rehabilitation in the setting of typical hearing by pure tone audiometry but poor speech understanding. A diagnosis of ANSD was made based on acoustic brainstem response (ABR), distortion product otoacoustic emission, and acoustic reflex testing.

Understanding Patient Utilization Patterns of Cochlear Implant Processors.

Objective: To evaluate the extent of benefit the second processor provides and to better understand utilization patterns regarding cochlear implant (CI) sound processors.

Background: Institutional contracts determine the external CI sound processor hardware that a patient is eligible for. Despite the high prevalence of CI worldwide, there is a paucity in the literature regarding patient preferences and how patients utilize provided external hardware.

Early educational attainment in children with major congenital anomaly in the UK.

Objective: To describe early educational attainment and special educational needs (SEN) provision in children with major congenital anomaly (CA) compared with peers.

Design: Analysis of educational data linked to the ongoing Born in Bradford cohort study. Confounders were identified via causal inference methods and multivariable logistic regression performed.

Educational attainment of children with congenital heart disease in the United Kingdom.

Background: Educational attainment in children with congenital heart disease (CHD) within the UK has not been reported, despite the possibility of school absences and disease-specific factors creating educational barriers.

Methods And Results: Children were prospectively recruited to the Born in Bradford birth cohort between March 2007 and December 2010. Diagnoses of CHD were identified through linkage to the congenital anomaly register and independently verified by clinicians.

Risk assessment of survival and morbidity of infants born at <24 completed weeks of gestation.

Background: Infants born at the threshold of viability have a high risk of mortality and morbidity. The British Association of Perinatal Medicine (BAPM) provided updated guidance in 2019 advising a risk-based approach to balancing decisions about active versus redirected care at birth.

Aims: To determine survival and morbidity of infants born between 22 and 24 completed weeks of gestation.

Preliminary results on validity and reliability from two prospective cohort studies on a new Neonatal Coma Score.

Objective: To collect data on content/face validity and interobserver agreement for a Neonatal Coma Score (NCS) in well full-term neonates and on construct validity in unwell and preterm babies, specifically how the NCS changed with gestational age and illness.

Design: Prospective cohort studies.

Setting: Two UK tertiary neonatal units (Sheffield and Leeds).

Fetal alcohol syndrome in the UK.

Objective: To determine the incidence of fetal alcohol syndrome (FAS) in the UK in children aged 0-16 years.

Design: Active surveillance was undertaken through the British Paediatric Surveillance Unit between October 2018 and October 2019 inclusive. Data were collected from reporting clinicians using standardised questionnaires.

A Phase Ib Trial of AVID200, a TGFβ 1/3 Trap, in Patients with Myelofibrosis.

Purpose: Myelofibrosis (MF) is a clonal myeloproliferative neoplasm characterized by systemic symptoms, cytopenias, organomegaly, and bone marrow fibrosis. JAK2 inhibitors afford symptom and spleen burden reduction but do not alter the disease course and frequently lead to thrombocytopenia. TGFβ, a pleiotropic cytokine elaborated by the MF clone, negatively regulates normal hematopoiesis, downregulates antitumor immunity, and promotes bone marrow fibrosis.

Early Recognition and Treatment for the Optimal Care of Individuals With Peripartum Cardiomyopathy.

Peripartum cardiomyopathy (PPCM) is a life-threatening pregnancy-associated condition that often develops within the last month of pregnancy and up to 5 months postpartum. Although it is uncommon, the incidence in the United States is on the rise, especially among Black individuals. Early recognition and treatment are crucial for long-term health and the recovery of left ventricular ejection fraction.

Thinking about God discourages dehumanization of religious outgroups.

In seven studies, six with American Christians and one with Israeli Jews (total = 2,323), we examine how and when belief in moralizing gods influences dehumanization of ethno-religious outgroups. We focus on dehumanization because it is a key feature of intergroup conflict. In Studies 1-6, participants completed measures of dehumanization from their own perspectives and also from the perspective of God, rating the groups' humanity as they thought God would rate it, or wish for them to rate it.

Decreasing early hypoglycemia frequency in at-risk newborns after implementing a new hypoglycemia screening algorithm.

Background: Neonatal hypoglycemia may affect long-term neurodevelopment.

Methods: Quality improvement (QI) initiative for Mother-Baby-Unit (MBU) admissions (birthweight ≥ 2100 g; ≥35 weeks' gestation) over two epochs from 2016-2019 to reduce the frequency of early (≤3 h) neonatal hypoglycemia in small and large newborns.

Intervention: New algorithm using Olsen's growth curves, hypoglycemia thresholds of <2.

PD-1 inhibition in advanced myeloproliferative neoplasms.

Myelofibrosis (MF) is a clonal stem cell neoplasm characterized by abnormal JAK-STAT signaling, chronic inflammation, cytopenias, and risk of transformation to acute leukemia. Despite improvements in the therapeutic options for patients with MF, allogeneic hematopoietic stem cell transplantation remains the only curative treatment. We previously demonstrated multiple immunosuppressive mechanisms in patients with MF, including increased expression of programmed cell death protein 1 (PD-1) on T cells compared with healthy controls.

The Term Newborn: Postnatal Screening and Testing.

Prenatal genetic screening, including evaluation for inherited genetic disorders, aneuploidy risk assessment, and sonographic assessment, combined with a thorough newborn examination and standard newborn screening, including blood, hearing, and congenital heart disease screening, can reveal conditions requiring further evaluation after delivery. Abnormal prenatal or newborn screening results should prompt additional diagnostic testing guided by maternal fetal medicine, perinatal genetics, or pediatric specialists.

Faith and science mindsets as predictors of COVID-19 concern: A three-wave longitudinal study.

The COVID-19 pandemic allowed for a naturalistic, longitudinal investigation of the relationship between faith and science mindsets and concern about COVID-19. Our goal was to examine two possible directional relationships: (Model 1) COVID-19 concern ➔ disease avoidance and self-protection motivations ➔ science and faith mindsets versus (Model 2) science and faith mindsets ➔ COVID-19 concern. We surveyed 858 Mechanical Turk workers in three waves of a study conducted in March, April, and June 2020.

The effects of increased pollution on COVID-19 cases and deaths.

The SARS-COV-2 virus, also known as the coronavirus, has spread around the world. A growing literature suggests that exposure to pollution can cause respiratory illness and increase deaths among the elderly. However, little is known about whether increases in pollution could cause additional or more severe infections from COVID-19, which typically manifests as a respiratory infection.

Genetic testing in patients with possible foetal alcohol spectrum disorder.

Objective: To assess the diagnostic yield of genetic conditions in patients referred to a regional genetics service to consider a diagnosis of foetal alcohol spectrum disorder.

Design: Retrospective case series.

Setting: A regional genetics centre in Yorkshire.

Putting the guidelines to work: moving from undergraduate physiology curricular guidelines to program development and improvement.

The first curricular guidelines for undergraduate physiology programs, currently under development by the Physiology Majors Interest Group (P-MIG), outline learning outcomes applicable for a wide range of physiology and physiology-related programs with diverse student populations. These outcomes for knowledge of core physiological concepts, professional skills, and advising provide a standard for undergraduate physiology education and a benchmark for student learning. Evaluation of how programs meet the curricular guidelines and assessment of the impact of programmatic approaches on student learning are essential for programmatic improvement.

Professional skills for physiology majors: defining and refining.

Changing labor markets require a workforce that is broadly trained for a variety of possible careers. Recognizing this, government and industry representatives, along with students and their families, are encouraging universities and colleges to focus more on developing transferable skills to maximize employability of their graduates. In response, academic institutions and professional organizations have begun to develop lists of transferable professional skills that they expect students to have acquired on graduation.

God. . . Karma, Jinn, spirits, and other metaphysical forces.

Humans have a natural tendency to explain events as caused by metaphysical or supernatural beings and forces. Much of the research in the psychology of religion over the past few years has focused on explanations and experiences involving a person-like God, whether God is authoritarian and/or benevolent, and the extent to which people think of God as being involved in human affairs. Yet many theists think of God in more abstract terms.

Undergraduate biological sciences and biotechnology students' reflective essays focus on descriptive details of experiential learning experiences.

Experiential learning experiences (ELEs), opportunities for students to apply knowledge and skills critically in a hands-on environment, are fundamental to the apprenticeship model of biological and biotechnological sciences. ELEs enhance student-learning gains, increase career readiness, and provide important networking opportunities. However, students do not often recognize the benefits of ELEs.