Publications by authors named "Kathryn J Domanchuk"
People with lower extremity peripheral artery disease (PAD) have increased oxidative stress, impaired mitochondrial activity, and poor walking performance. NAD+ reduces oxidative stress and is an essential cofactor for mitochondrial respiration. Oral nicotinamide riboside (NR) increases bioavailability of NAD+ in humans.
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- * The study will include 212 participants with PAD and a BMI of 25 or higher, who will be randomized to receive either a behavioral weight loss intervention (via group sessions, a smartphone app, and phone coaching) or to focus solely on walking exercise.
- * Key outcomes will measure improvements in walking distance after 12 months, alongside other physical activity metrics, dietary quality, and muscle health, ultimately seeking to enhance the treatment approach for PAD patients who are also overweight or obese.