Feline hepatobiliary neoplasia and mistaken age.

A cat, thought to be 5 years old, and with reduced appetite and weight loss, was presented for dental cleaning and extractions. Bile duct origin hepatic carcinoma was diagnosed. The progression of iris degeneration, dental disease, histological renal lesions, spondylosis, and hepatobiliary neoplasia suggest this cat was closer to 10 years old.

Structure determination of a partially ordered layered silicate material with an NMR crystallography approach.

Structure determination of layered materials can present challenges for conventional diffraction methods due to the fact that such materials often lack full three-dimensional periodicity since adjacent layers may not stack in an orderly and regular fashion. In such cases, NMR crystallography strategies involving a combination of solid-state NMR spectroscopy, powder X-ray diffraction, and computational chemistry methods can often reveal structural details that cannot be acquired from diffraction alone. We present here the structure determination of a surfactant-templated layered silicate material that lacks full three-dimensional crystallinity using such an NMR crystallography approach.

Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia.

B cell acute lymphoblastic leukemia (B-ALL) is frequently associated with mutations or chromosomal translocations of genes encoding transcription factors. Conditional deletion of genes encoding the E26-transformation-specific transcription factors, PU.1 and Spi-B, in B cells (ΔPB mice) leads to B-ALL in mice at 100% incidence rate and with a median survival of 21 wk.