Publications by authors named "Kathryn Henckels"
Autologous cell therapy has proven to be an effective treatment for hematological malignancies. Cell therapies for solid tumors are on the horizon, however the high cost and complexity of manufacturing these therapies remain a challenge. Routinely used open steps to transfer cells and reagents through unit operations further burden the workflow reducing efficiency and increasing the chance for human error.
View Article and Find Full Text PDFThe calcium-activated chloride channel, TMEM16A, is involved in airway hydration and bronchoconstriction and is a promising target for respiratory disease. Drug development efforts around channels require an electrophysiology-based assay for identifying inhibitors or activators. TMEM16A has proven to be a difficult channel to record on automated electrophysiology platforms due to its propensity for rundown.
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- * Researchers screened around 580,000 compounds and found that anthelmintics like niclosamide and nitazoxanide effectively block TMEM16A, showing better efficacy than traditional β-agonists in harsh conditions, fully bronchodilating airways.
- * This study highlights the potential of repurposing TMEM16A antagonists such as niclosamide and nitazoxanide for treating severe asthma and COPD, as well as possibly expanding their use in cancer and infectious