Publications by authors named "Kathryn F Elliott"
Simple and effective bacterial-based intratumoral cancer immunotherapy.
J Immunother Cancer
September 2021
Article Synopsis
- Researchers tested a slow-release emulsion of killed mycobacteria (CFA) for treating tumors in mice, dogs, horses, and human cancer patients, analyzing its effects on survival and immune response.
- * In preclinical trials, significant tumor regression and extended survival were observed across all species, with immune cell analysis indicating that early neutrophil infiltration predicted treatment success.
- * The treatment was well tolerated in human patients, and CT scans showed tumor regression, particularly in a late-stage renal cancer patient.
Objective: To develop a standardized meal challenge test by assessing associations between food-withheld preprandial (ie, fasting) and postprandial triglyceride concentrations, determining the most appropriate sampling time to detect the peak concentration (highest postprandial concentration), and estimating reference intervals for fasting and postprandial concentrations in healthy dogs.
Animals: 12 lean healthy mixed-breed dogs.
Procedures: Dogs were fed a dry commercially available diet (fat, 31% metabolizable energy) for 3 weeks.