Cost-Effectiveness of [Tc]Tilmanocept Relative to [Tc]Sulfur Colloid for Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer.

Background: Several studies have demonstrated varying rates of efficacy, reliability, and sensitivity of sentinel lymph node biopsy (SLNB) in identifying occult nodal disease for early stage oral cavity squamous cell carcinoma (OCSCC) depending on the radionuclide agent utilized. No head-to-head comparison of cost or clinical outcomes of SLNB when utilizing [Tc]tilmanocept versus [Tc]sulfur colloid has been performed. The goal of this study was to develop a decision model to compare the cost-effectiveness of [Tc]tilmanocept versus [Tc]sulfur colloid in early stage OCSCC.