Clinical impact of selective and nonselective beta-blockers on survival in patients with ovarian cancer.

Background: Preclinical evidence has suggested that sustained adrenergic activation can promote ovarian cancer growth and metastasis. The authors examined the impact of beta-adrenergic blockade on the clinical outcome of women with epithelial ovarian, primary peritoneal, or fallopian tube cancers (collectively, epithelial ovarian cancer [EOC]).

Methods: A multicenter review of 1425 women with histopathologically confirmed EOC was performed.

The course of lichen sclerosus diagnosed prior to puberty.

Study Objective: To help determine the long-term course of girls diagnosed with lichen sclerosus before puberty.

Design: Retrospective chart review and follow-up interview.

Setting: Washington University pediatric gynecology and dermatology clinics.

Eptifibatide induced profound thrombocytopenia in a patient with pelvic malignancy: A case report.

► Eptifibatide is associated with profound thrombocytopenia and thrombosis secondary to a HITT-like mechanism associated with drug-dependant antibodies. ► Caution with eptifibatide use is needed in those pre-disposed to hypercoaguability, particularly those with an underlying malignancy.