Burden of cystic fibrosis in children <12 years of age prior to the introduction of CFTR modulator therapies.

Background: Cystic fibrosis (CF) is a genetic, multisystemic, progressive and life-shortening disease caused by mutations in the CF transmembrane conductance regulator () gene. Different genotypes have been linked to variations in disease progression among people with CF. The burden of illness (BOI) in children with CF is incompletely characterised, particularly as it relates to genotypes prior to the availability of the first CFTR modulators.

Pregravid contraceptive use and fecundability: prospective cohort study.

Objective: To evaluate the association between pregravid use of a variety of contraceptive methods and subsequent fecundability.

Design: Prospective cohort study.

Setting: Denmark and North America, 2007-19.

Association Between Male Use of Pain Medication and Fecundability.

Administration of pain relievers has been associated with both lower and higher risks of adverse reproductive outcomes in animals. In the sole investigation of male pain-reliever use and human fertility carried out to date, Smarr et al. (Hum Reprod.