Publications by authors named "Kathryn Arrambide"
Article Synopsis
- Small-bowel adenocarcinoma (SBA) is a rare cancer with no established treatment for advanced cases beyond the initial chemotherapy, and it often shows higher microsatellite instability (MSI-H) which may respond to immune therapy like pembrolizumab.
- In a study of 40 previously treated patients, pembrolizumab was administered every three weeks, but only 8% showed partial responses, while the majority experienced disease progression and significant adverse effects.
- The study found that while the overall response didn't meet expectations, a subset of patients with MSI-H tumors showed promising responses, suggesting further investigation in biomarker-specific treatment could be valuable.
The Phylum Microsporidia comprises >1,200 species, only 15 of which are known to infect humans, including the genera Trachipleistophora, Pleistophora, and Brachiola. We report an infection by Tubulinosema sp. in an immunosuppressed patient.
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