Publications by authors named "Kathrin S Copley"
Biochemistry
September 2009
Article Synopsis
- Eclosion hormone (EH) is crucial for insects to emerge from their exoskeletons, but its structure was previously unknown, leading researchers to use a computational method to model the Manduca sexta EH.
- The predicted model features 55% helical content, an unstructured N-terminus, and a solvent-exposed loop, and its validity was confirmed through various experimental techniques, including circular dichroism and mass spectrometry.
- The study also suggests that the EH structures of other species, like Bombyx mori and Drosophila melanogaster, are similar, and key functional residues are found in conserved regions that play important roles in the hormone's activity.
