Prostaglandin D strengthens human endothelial barrier by activation of E-type receptor 4.

Life-threatening inflammatory conditions such as acute respiratory distress syndrome or sepsis often go hand in hand with severe vascular leakage. During inflammation, endothelial cell integrity and intact barrier function are crucial to limit leukocyte and plasma extravasation. Prostaglandin D (PGD) is a potent inflammatory lipid mediator with vasoactive properties.