Publications by authors named "Kathrin Putke"
The prerequisite for successful HLA genotyping is the integrity of the large allele reference database IPD-IMGT/HLA. Consequently, it is in the laboratories' best interest that the data quality of submitted novel sequences is high. However, due to its long and variable length, the gene HLA-DRB1 presents the biggest challenge and as of today only 16% of the HLA-DRB1 alleles in the database are characterized in full length.
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- MICA is a stress-induced ligand that activates NK and T cell responses, playing a crucial role in anti-tumor immunity.
- The study found high frequencies of duplications (1%) and deletions (0.4%) of the MICA gene across over two million individuals, with significant variations among different ethnic groups, reaching up to 9.2% in Mexico.
- The findings suggest that these copy number variations result from independent recombination events and highlight the need for more research on their potential links to diseases, particularly in cancer studies.
HLA-E is a member of the nonclassical HLA class Ib genes. Even though it is structurally highly similar to the classical HLA class Ia genes, it is less diverse and only 45 alleles and 12 proteins were known in December 2019 (IPD-IMGT/HLA, release 3.38.
View Article and Find Full Text PDFMICA and MICB are ligands of the NKG2D receptor and thereby influence NK and T cell activity. gene polymorphisms, expression levels and the amount of soluble MICA/B in the serum have been linked to autoimmune diseases, infections, and cancer. In hematopoietic stem cell transplantation, matching between donor and patient has been correlated with reduced acute and chronic graft-vs.
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