Publications by authors named "Kathrin Entleutner"
Inflammatory immune responses induced by lipopolysaccharides (LPS) of gram-negative bacteria play an important role in the pathogenesis of preterm labor and delivery, and in neonatal disorders. To better characterize LPS-induced inflammatory response, we determined the cytokine profile of umbilical cord blood mononuclear cells (UBMC) stimulated with LPS of seven vaginal gram-negative bacteria commonly found in pregnant women with preterm labor and preterm rupture of membrane. UBMC from ten newborns of healthy volunteer mothers were stimulated with purified LPS of Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, Proteus mirabilis, Acinetobacter calcoaceticus, Citrobacter freundii, and Pseudomonas aeruginosa.
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- Neonatal sepsis poses a significant risk to preterm infants, prompting the development of a new model using humanized mice to study the condition and test existing treatments like Betamethasone and Indomethacin.
- In the study, humanized mice were infected with E. coli to observe the immune response and the effects of the treatments on survival and immune system functions.
- Results showed a functional human immune response in the mice, but Indomethacin had little impact, while Betamethasone may harm the child's immune system long-term, highlighting the need for careful consideration in clinical use.