Publications by authors named "Kathrin Engels"
Purpose: Thyroid hormones (TH) are important for brain development and central nervous system (CNS) function. Disturbances of thyroid function occur with higher prevalence in the ageing population and may negatively impact brain function.
Methods: We investigated the age impact on behavior in young adult and old male mice (5 vs.
Clinical manifestation of hyperthyroidism and hypothyroidism vary with age, with an attenuated, oligosymptomatic presentation of thyroid dysfunction (TD) in older patients. We asked, whether in rodents TD phenotypes are influenced by age and whether this involves changes in systemic and/or organ thyroid hormone (TH) signaling. Chronic hyper- or hypothyroidism was induced in male mice at different life stages (5, 12, and 20 months).
View Article and Find Full Text PDFBackground: Sex and age play a role in the prevalence of thyroid dysfunction (TD), but their interrelationship for manifestation of hyper- and hypothyroidism is still not well understood. Using a murine model, we asked whether sex impacts the phenotypes of hyper- and hypothyroidism at two life stages.
Methods: Hyper- and hypothyroidism were induced by i.
Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo.
Proc Natl Acad Sci U S A
December 2017
Article Synopsis
- - Thyroid hormone (TH) and its receptors (TRs) can act through two pathways: the traditional type 1 pathway involves gene expression by binding to DNA, while a nontraditional type 3 pathway activates other cellular processes quickly without affecting gene expression.
- - Researchers created mutant mice that cannot bind DNA via TRs, which helped them discover that key physiological effects of TH, like heart rate and blood sugar levels, can still occur through the noncanonical signaling pathway.
- - The study demonstrates that noncanonical TR signaling has significant effects on metabolism and heart function, suggesting that thyroid hormone's actions are more complex than previously believed and not solely dependent on altering gene transcription.
Protocols for induction of hyperthyroidism in mice are highly variable and mostly involve short-term thyroid hormone (TH) treatment. In addition, little is known about a possible influence of sex on experimental TH manipulation. Here we analyzed the efficacy of intraperitoneal vs.
View Article and Find Full Text PDFBackground: Thyroid dysfunction is more common in the female population, however, the impact of sex on disease characteristics has rarely been addressed. Using a murine model, we asked whether sex has an influence on phenotypes, thyroid hormone status, and thyroid hormone tissue response in hyper- and hypothyroidism.
Methods: Hypo- and hyperthyroidism were induced in 5-month-old female and male wildtype C57BL/6N mice, by LoI/MMI/ClO4 (-) or T4 i.
Background: Clinical features of thyroid dysfunction vary with age, and an oligosymptomatic presentation of hyperthyroidism is frequently observed in the elderly. This suggests age modulation of thyroid hormone (TH) action, which may occur, for example, by alterations in TH production, metabolism and/or TH action in target organs.
Objectives: In this paper, we address possible changes in TH transporter expression in liver tissues as a mechanism of age-dependent variation in TH action.
Background: In the liver the tight junction protein claudin-1 plays an important role in bile secretion by maintaining the paracellular barrier of bile canaliculi and the bile duct. A diminished bile excretion has been found in hypothyroid patients, and the prevalence of gallstones is increased in hypothyroidism. This association, however, only applies for men and is in contrast to the well-established female preponderance of biliary disease in the general population.
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