Publications by authors named "Kathrin Copley"
Article Synopsis
- Eclosion hormone (EH) is crucial for insects to emerge from their exoskeletons, but its structure was previously unknown, leading researchers to use a computational method to model the Manduca sexta EH.
- The predicted model features 55% helical content, an unstructured N-terminus, and a solvent-exposed loop, and its validity was confirmed through various experimental techniques, including circular dichroism and mass spectrometry.
- The study also suggests that the EH structures of other species, like Bombyx mori and Drosophila melanogaster, are similar, and key functional residues are found in conserved regions that play important roles in the hormone's activity.
Exenatide is a 39 amino acid incretin mimetic for the treatment of type 2 diabetes, with glucoregulatory activity similar to glucagon-like peptide-1 (GLP-1). Exenatide is a poor substrate for the major route of GLP-1 degradation by dipeptidyl peptidase-IV, and displays enhanced pharmacokinetics and in vivo potency in rats relative to GLP-1. The kidney appears to be the major route of exenatide elimination in the rat.
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