Publications by authors named "Kathrin Buder"
Article Synopsis
- Sphingosine-1-phosphate lyase insufficiency syndrome (SPLIS) is a rare genetic disorder linked to severe health issues like nephrotic syndrome, adrenal insufficiency, and various systemic symptoms, primarily caused by mutations in the SGPL1 gene.
- A study of 76 SPLIS patients found that overall survival is around 50%, with survival influenced by factors such as age at diagnosis, organ involvement, whether the patient received a kidney transplant, and specific SGPL1 genotypes.
- Children diagnosed with SPLIS nephropathy before age one have a significantly worse survival rate compared to those diagnosed after one year, highlighting the importance of early diagnosis and potential interventions.
Background: Vesicoureteral reflux (VUR) is common in children and adolescents undergoing kidney transplantation (KTx) and may adversely affect allograft kidney function.
Methods: To explore the current management of symptomatic native and allograft VUR in pediatric KTx recipients, an online survey was distributed to European surgical transplant professionals.
Results: Surgeons from 40 pediatric KTx centers in 18 countries participated in this survey.
Background: Children with non-refluxing primary megaureter are mostly managed by a watchful approach with close follow-up and serial imaging.
Objectives: This systematic review and meta-analysis aimed to determine whether there is sufficient evidence to support the current non-surgical management strategy in these patients.
Data Sources: A comprehensive search including electronic literature databases, clinical trial registries, and conference proceedings was performed.
Background: Vesico-ureteral reflux (VUR) is considered to be a risk factor for recurrent febrile urinary tract infections and impaired renal transplant survival.
Methods: An online survey supported by the European Society for Paediatric Nephrology was designed to evaluate current management strategies of VUR in native and transplanted kidneys of recipients aged <18 years.
Results: Seventy-three pediatric transplant centers from 32 countries contributed to the survey.
Background: Acute graft-versus-host disease (aGvHD) is a major cause of morbidity and mortality after haematopoietic stem cell transplantation (HSCT), occurring in 8% to 85% of paediatric recipients. Currently, the therapeutic mainstay for aGvHD is treatment with corticosteroids. However, there is no established standard treatment for steroid-refractory aGvHD.
View Article and Find Full Text PDFBackground: Chronic graft-versus-host disease (cGvHD) is a major cause of morbidity and mortality after haematopoietic stem cell transplantation, occurring in 6% to 65% of the paediatric recipients. Currently, the therapeutic mainstay for cGvHD is treatment with corticosteroids, frequently combined with other immunosuppressive agents in people with steroid-refractory manifestations. There is no established standard treatment for steroid-refractory cGvHD.
View Article and Find Full Text PDFBackground: RGT is a major cause for early graft loss after KTx. Although evidence-based recommendations are lacking, aP is often used to prevent RGT. This systematic review aimed to determine the effectiveness and safety of aP in adult and pediatric KTx recipients.
View Article and Find Full Text PDFBackground: Knowledge of the baseline risk of febrile urinary tract infections in patients with primary non-refluxing megaureter can help clinicians to make informed decisions for offering continuous antibiotic prophylaxis.
Objective: The primary objective of this systematic review was to determine the pooled prevalence of febrile urinary tract infections in patients with primary non-refluxing megaureter selected for primary non-surgical management independent of associated attributed risk factors at initial presentation in order to assess the value of continuous antibiotic prophylaxis.
Methods: MEDLINE, EMBASE, and Cochrane Controlled Trials Register electronic databases were searched for eligible studies without language and time restriction.
Background: Renal graft thrombosis (RGT) is one of the main causes for early graft loss in pediatric kidney transplantation (KTx). Despite the lack of evidence-based recommendations, antithrombotic prophylaxis (aP) is used to prevent RGT.
Methods: An online survey supported by the European Society for Pediatric Nephrology was developed to investigate the current practice of aP in pediatric KTx recipients <18 years.
Article Synopsis
- The study examined the long-term health-related quality of life (HRQoL) and psychological adjustment in children who previously suffered from haemolytic-uraemic syndrome (HUS).
- Parents of preschoolers reported lower energy levels but no significant behavioral issues, whereas school-age children showed a normal or better self-reported HRQoL despite increased behavioral problems.
- Overall, there were no signs of depression or post-traumatic stress disorder among the children, suggesting the need for healthcare providers to focus on behavioral challenges in school-aged kids and emotional wellbeing in preschool children post-HUS.
Unlabelled: Congenital anomalies of the kidney and urinary tract are common findings on fetal ultrasound. The aim of this prospective observational study was to describe outcome and risk factors in 115 patients born 1995-2001. All prenatally diagnosed children were stratified into low- and high-risk group and followed postnatally clinically and by imaging at defined endpoints.
View Article and Find Full Text PDFBackground: Little is known about health-related quality of life (HRQoL) and mental health of parents having children with a history of hemolytic uremic syndrome (HUS).
Methods: This study included 63 mothers and 58 fathers of a cohort of 63 HUS-affected children. At assessment, the mean time since a child experienced an acute episode of HUS was 6.
Background: To investigate the long-term neurodevelopmental outcome in children after hemolytic uremic syndrome (HUS) and to compare outcome dependent on central nervous system (CNS) involvement during HUS.
Methods: A single-center retrospective cohort of 47 children was examined at a median age of 10.6 (range 6-16.