Publications by authors named "Kathrin Bernhart"
Article Synopsis
- Immunotherapy is the primary treatment for advanced hepatocellular carcinoma (aHCC), but many patients still face disease progression despite initial responses, which has led to exploring combination therapies, including radiotherapy.
- The study analyzed patients who received immune checkpoint inhibitors (ICIs) alongside radiotherapy to assess both effectiveness and adverse effects, focusing on those treated between 2016 and 2021.
- Out of six patients, different radiotherapy techniques were employed with no severe adverse effects noted, and five of the six patients achieved long-term tumor control.
Human telomerase reverse transcriptase (TERT) gene encodes the catalytic subunit of telomerase and is located on chromosome 5p15, a genomic region which was found to be associated with multiple cancer types. But no associations with colorectal cancer (CRC) have been reported until recently. Therefore, the purpose of this study was to investigate the influence of seven single-nucleotide polymorphisms (SNPs) of TERT on susceptibility to colorectal polyps and CRC.
View Article and Find Full Text PDFBackground: X-ray repair cross complementation group 1 (XRCC1) plays a key role in base excision repair. The purpose of this study was to examine the association of two genetic polymorphisms in XRCC1 (rs1799782 and rs25487) with risk of colorectal polyps and colorectal cancer (CRC).
Methods: In the ongoing colorectal cancer study of Austria (CORSA), a total of 3091 Caucasian participants was genotyped using 5'-nuclease TaqMan assays.