Publications by authors named "Kathleen S Magee"

Article Synopsis
  • Orofacial clefts, including cleft palate only (CPO) and cleft lip with or without palate (CL/P), are prevalent developmental disorders that create various clinical and psychological challenges.
  • In a study involving around 17 million genetic markers among sub-Saharan African populations, researchers identified new genetic loci associated with CPO on chromosomes 2 and 19, suggesting potential biological mechanisms.
  • The study confirmed the significance of previously known loci such as 8q24 for CL/P, along with the replication of other established genes like PAX7 and VAX1, contributing to our understanding of these conditions.
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While several studies have investigated maternal exposures as risk factors for oral clefts, few have examined paternal factors. We conducted an international multi-centered case-control study to better understand paternal risk exposures for oral clefts (cases = 392 and controls = 234). Participants were recruited from local hospitals and oral cleft repair surgical missions in Vietnam, the Philippines, Honduras, and Morocco.

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Background: Several lifestyle and environmental exposures have been suspected as risk factors for oral clefts, although few have been convincingly demonstrated. Studies across global diverse populations could offer additional insight given varying types and levels of exposures.

Methods: We performed an international case-control study in the Democratic Republic of the Congo (133 cases, 301 controls), Vietnam (75 cases, 158 controls), the Philippines (102 cases, 152 controls), and Honduras (120 cases, 143 controls).

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