Feasibility Study: Towards a Robot-Assisted Gait Training in Ophthalmological Rehabilitation.

The idea of using mobile assistance robots for gait training in rehabilitation has been increasingly explored in recent years due to the associated benefits. This paper describes how the previous results of research and praxis on gait training with a mobile assistance robot in orthopedic rehabilitation can be transferred to ophthalmic-related orientation and mobility training for blind and visually impaired people. To this end, the specific requirements for such orientation and mobility training are presented from a therapeutic perspective.

10-Year Results of FLEx Refractive Surgery.

Purpose: To evaluate the 10-year results of femtosecond lenticule extraction (FLEx) for treatment of myopia and myopic astigmatism.

Methods: This long-term follow-up of a prospective clinical trial was conducted at HELIOS Klinikum Erfurt and Phillips University of Marburg, Germany. In 2006, 108 eyes underwent the FLEx procedure.

10-Year Results of Small Incision Lenticule Extraction.

Purpose: To evaluate the 10-year results of refractive lenticule extraction using the small incision lenticule extraction (SMILE) technique for treatment of myopia and myopic astigmatism.

Methods: In 2008-2009, the first 91 eyes were treated using a novel surgical technique (SMILE), in which a refractive lenticule of intrastromal corneal tissue is removed through a small incision, completely eliminating flap cutting. A total of 56 of 91 eyes of the original treatment group volunteered for reexamination 10 years after surgery, including uncorrected and corrected distance visual acuity, objective and manifest refraction, and evaluation of the interface and corneal surface by slit-lamp examination.

Interface morphology and gas production by a refractive 347 nm ultraviolet femtosecond laser: Comparison with established laser systems.

Purpose: To evaluate gas production and interface quality after refractive lenticule creation. A new ultraviolet (UV) 347 nm femtosecond laser was compared with the FS200 and the Visumax lasers.

Setting: Department of Anatomy II, University of Erlangen-Nürnberg, Erlangen, Germany.

Influence of the beam profile crosslinking setting on changes in corneal topography and tomography in progressive keratoconus: Preliminary results.

Purpose: To evaluate the effect of accelerated corneal crosslinking (CXL) with a "higher peripheral intensity" profile setting compared with a standard "top hat" profile setting performed using different CXL systems.

Setting: Department of Ophthalmology, University Hospital Carl Gustav Carus, Dresden, Germany.

Design: Retrospective case series.

[Dacryoendoscopic Surgery-Factors Influencing Postoperative Results].

Background: Dacryoendoscopy (DE) is an established method in lacrimal surgery. Long-term follow-up-analyses of this surgery are of great interest. Here, factors influencing postoperative success rates should be considered to elect suitable patients.

Topical administration of regorafenib eye drops: phase I dose-escalation study in healthy volunteers.

Aim: Regorafenib is a multikinase inhibitor under investigation for use in neovascular age-related macular degeneration. In this phase I study, regorafenib eye drops were administered to healthy volunteers to provide information on safety, tolerability and systemic exposure.

Methods: This was a single-centre, randomized, double-masked, parallel-group, dose-escalation, placebo-controlled study.

Repeatability and Agreement of Central Corneal Thickness and Keratometry Measurements between Four Different Devices.

To estimate repeatability and comparability of central corneal thickness (CCT) and keratometry measurements obtained by four different devices in healthy eyes. Fifty-five healthy eyes from 55 volunteers were enrolled in this study. CCT (IOLMaster 700, Pentacam HR, and Cirrus HD-OCT) and keratometry readings (IOLMaster 700, Pentacam HR, and iDesign) were measured.

Repeatability and agreement in optical biometry of a new swept-source optical coherence tomography-based biometer versus partial coherence interferometry and optical low-coherence reflectometry.

Purpose: To estimate the repeatability of biometric parameters obtained with a new swept-source biometer and to compare the agreement with that of partial coherence interferometry (PCI) and optical low-coherence reflectometry (OLCR).

Setting: Department of Ophthalmology, Helios Hospital Erfurt, Erfurt, Julius-Maximilians University, Würzburg, and Philipps University, Marburg, Germany.

Design: Prospective comparative multicenter clinical study.

Five-year results of Small Incision Lenticule Extraction (ReLEx SMILE).

Background: To evaluate the 5-year results of Refractive Lenticule Extraction (ReLEx) as Small Incision Lenticule Extraction (SMILE) technique for treatment of myopia and myopic astigmatism.

Methods: In 2008/2009, the worldwide first 91 eyes were treated using a novel surgical technique (SMILE), where a refractive lenticule of intrastromal corneal tissue is removed though a small incision completely eliminating flap-cutting. 56 out of 91 eyes of the original treatment group volunteered for re-examination 5 years after surgery.

Topographic Findings of the Porcine Cornea.

The porcine eye is often used as an ex vivo animal model in ophthalmological research. It is well suited for investigations concerning refractive surgery; however, corneal topography data are scarce. This study investigated the corneal topography and pachymetry of the porcine eye to provide further reproducible data.

Five-year results of refractive lenticule extraction.

Purpose: To evaluate the 5-year results of femtosecond laser-assisted refractive lenticule extraction (ReLEx-FLEx) for the treatment of myopia and myopic astigmatism.

Setting: Departments of Ophthalmology, Helios Klinikum Erfurt, Erfurt, and Phillips Universität Marburg, Marburg, Germany.

Design: Prospective clinical trial.

An in vitro study on focusing fs-laser pulses into ocular media for ophthalmic surgery.

Background And Objective: To investigate femtosecond (fs)-laser patterns within ocular media for ophthalmic surgery.

Methods: Vitreous and crystalline lens tissue from porcine eyes were treated with 2-dimensional fs-laser patterns and inspected under the optical microscope. Time resolved pump-probe experiments were conducted on vitreous tissue and gelatin, which should act as a model for crystalline lens tissue.

A modified Hartmann-Shack aberrometer for measuring stray light in the anterior segment of the human eye.

Purpose: To examine the use of a modified Hartmann-Shack wave front aberrometer (WASCA; Carl Zeiss Meditec AG, Germany) to measure objective stray light caused by forward light scatter from the anterior segment of the human eye.

Setting: HELIOS Klinikum Erfurt/Institute of Biomedical Engineering and Informatics, Ilmenau University of Technology, Germany.

Method: Scatter parameters, including the Michelson contrast and cross-sectional area at half height (CAHM) were examined in Hartmann-Shack images from ten subjects with a cataract in one eye and an intraocular lens (IOL) in the other.

Vector analysis of myopic astigmatism corrected by femtosecond refractive lenticule extraction.

Purpose: To evaluate the visual outcome of refractive lenticule extraction in eyes with myopic astigmatism using the Visumax femtosecond laser.

Setting: Department of Ophthalmology, HELIOS Klinikum Erfurt, Erfurt, Germany.

Design: Nonrandomized clinical trials.

Femtosecond lenticule extraction (ReLEx) for correction of hyperopia - first results.

Background: This prospective study focused on the results of a novel method for refractive correction, femtosecond lenticule extraction (ReLEx®) in hyperopia, and reports the first 47 eyes.

Methods: In 47 hyperopic eyes (26 patients), both a flap and a lenticule of intrastromal corneal tissue were simultaneously cut utilizing the Carl Zeiss Meditec AG (CZM) 200 kHz VisuMax femtosecond laser system. Thereafter, the lenticule was manually removed and the flap repositioned.

Analysis of optical side-effects of fs-laser therapy in human presbyopic lens simulated with modified contact lenses.

Background: In a single-blinded study, optical side-effects of a potential femtosecond (fs)-laser therapy in presbyopic human lenses were tested. Simulation of this therapy was carried out by applying fs-laser patterns into standard contact lenses (CL).

Methods: In the first part of the study, the influence of the numerical aperture on optical side-effects was investigated by comparing a typical fs-LASIK configuration to a fs-presbyopia treatment (n = 11).

Femtosecond laser treatment of the crystalline lens: a 1-year study of possible cataractogenesis in minipigs.

Background: To investigate the long-term stability and possible cataractogenesis after femtosecond laser treatment of the crystalline lens.

Methods: The crystalline lenses of ten Göttingen minipigs® underwent femtosecond laser treatment. During a subsequent 1-year follow-up, the pigs were monitored by means of slit-lamp examination of the anterior segment and Scheimpflug imaging of the lens.

Surface quality of porcine corneal lenticules after Femtosecond Lenticule Extraction.

Purpose: To determine the surface characteristics of porcine corneal lenticules after Femtosecond Lenticule Extraction.

Methods: The Carl Zeiss Meditec AG VisuMax® femtosecond laser system was used to create refractive corneal lenticules on 10 freshly isolated porcine eyes. The surface regularity on the corneal lenticules recovered was evaluated by assessing scanning electron microscopy images using an established scoring system.

Surface quality of human corneal lenticules after femtosecond laser surgery for myopia comparing different laser parameters.

Background: To determine the surface characteristics of human corneal lenticules after femtosecond laser surgery for myopia.

Methods: The Carl Zeiss Meditec AG VisuMax® femtosecond laser system was used for refractive correction called Femtosecond Lenticule Extraction on 24 myopic eyes. The surface regularity on the refractive corneal lenticules recovered was evaluated by assessing scanning electron microscopy images using an established scoring system.