Airline passenger misconduct: management implications for physicians.

Objective: The history and etiology of airline passenger misconduct are discussed and relevant medico-legal and management implications reviewed.

Method: The medical literature was reviewed and supplemented with internet searches for relevant information. Organizations including the Federal Aviation Administration, International Air Transport Association, Transportation Safety Board of Canada, and the Canadian Transportation Agency were contacted for unpublished information.

Serum monitoring of antipsychotic drug levels during concomitant administration of sertraline and antipsychotic medication.

Objective: To assess whether pharmacokinetic drug interactions occur when sertraline is added to antipsychotic medications.

Method: Forty-eight patients with remitted DSM-IV schizophrenia and comorbid major depression were randomized to placebo for 6 weeks or sertraline 50 mg for 4 weeks followed by sertraline 50 mg to 100 mg for 2 weeks for nonresponders. Treatment with the patients' usual antipsychotic continued.